Title |
Treatment with acyclovir five times daily may reduce the duration of primary herpetic oral lesions |
Clinical Question |
In children experiencing primary herpetic gingivostomatitis, does treatment with acyclovir, compared to no treatment, reduce the duration of oral lesions? |
Clinical Bottom Line |
Treatment with acyclovir 5 times daily could reduce the duration of primary herpetic oral lesions. (See Comments on the CAT below) |
Best Evidence |
|
PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
18843726 | Nasser/2008 | Children and young adults < 25 years of age with a diagnosis of primary herpetic gingivostomatitis | Systematic review | Key results | Two randomized controlled trials were included in this systematic review. One provided weak evidence that acyclovir is an effective treatment for primary herpetic gingivostomatitis. The results showed reduction in the number of individuals with oral lesions (risk ratio (RR) 0.10 (95% confidence interval (CI) 0.02 to 0.38)), new extraoral lesions (RR 0.04 (95% CI 0.00 to 0.65)), difficulty in eating (RR 0.14 (95% CI 0.03 to 0.58)), and drinking difficulties (RR 0.11 (95% CI 0.01 to 0.83)) after 8 days of treatment. | |
Evidence Search |
“Acyclovir”;[Mesh] AND &;”Stomatitis, Herpetic;[Mesh] AND Child;[Mesh] |
Comments on
The Evidence |
none |
Applicability |
Children experiencing primary herpetic gingivostomatitis |
Specialty |
(General Dentistry) |
Keywords |
Acyclovir, child, herpetic stomatitis, oral lesions, treatment
|
ID# |
491 |
Date of submission |
01/07/2010 |
E-mail |
riggsc@livemail.uthscsa.edu |
Author |
Christi Wengler |
Co-author(s) |
Chad Riggs |
Co-author(s) e-mail |
|
Faculty mentor |
Lina M. Cardenas, DDS |
Faculty mentor e-mail |
|
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Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
None available | |
|
Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
by Leslie Jean (San Antonio, TX) on 04/09/2012 After performing a PubMed search on this topic on April 9, 2012, it has been found that the article presented in this CAT is still the most recent and highest level of evidence available. | |