Title Vitamin D Supplementation May Reduce the Risk of Early Dental Implant Failure in Vitamin D-Deficient Patients
Clinical Question Does treatment of Vitamin D deficiency reduce the rate of early implant failure?
Clinical Bottom Line Vitamin D supplementation may reduce the risk of early dental implant failure in Vitamin D-deficient patients.
Best Evidence  
PubMed ID Author / Year Patient Group Study type
(level of evidence)
30443302Mangano/2018885 patients treated with 1,740 dental implantsRetrospective Cohort Study
Key resultsThis study did not demonstrate a significant relationship between low serum Vitamin D levels and early dental implant failure; however, there was a trend toward an increased incidence of early implant failure with lowering of serum vitamin D levels.
27888492Fretwurst/2016Two patientsCase report
Key resultsWith the limitation of this study, vitamin D deficient patients treated with vitamin D supplementation following early implant failure subsequently obtained successful implant placement.
25895415Bryce/2014One patientCase report
Key resultsOsseointegration of dental implants may fail in the presence of vitamin D deficiency.
Evidence Search “Dental implant vitamin D failure”
Comments on
The Evidence
The role of Vitamin D in the regulation of bone metabolism is well established. However, the potential effects of a Vitamin D deficiency in dentistry, and in the particular area of implant dentistry, is garnering clinical interest. Several modest case reports cite a potential association between low levels of serum vitamin D and failure of osseointegration of dental implants. These studies support the hypothesis that patients treated for a serum Vitamin D deficiency can be successfully rehabilitated with dental implants if the Vitamin D deficiency is corrected prior to implant placement. However, as this evidence is derived from case reports, and consequently represents a low quality of evidence, the results must be interpreted with a degree of caution. A larger, more robust, retrospective clinical study failed to establish a direct association between Vitamin D deficiency and early failure of dental implants. Nevertheless, the author did note a trend towards an increased incidence of early implant failure with lowering of serum vitamin D levels, which was not statistically significant (P=0.105). However, the study (n=885) also included a small number of patients (n=27) with severe Vitamin D deficiency (serum levels of vitamin D <10 ng/mL), who had an 11% early implant failure rate within the cohort. A direct association between early implant failure and serum Vitamin D level cannot be established; however, based on weak evidence there may be an association. Robust assessment of a patient’s medical history and general health is recommended prior to rehabilitation with dental implants.
Applicability Patients requiring dental implant treatment should have a comprehensive medical history taken, and where indicated be assessed for Vitamin deficiencies to improve overall health, and potentially increase the success of treatment.
Specialty (General Dentistry) (Oral Surgery) (Periodontics) (Prosthodontics)
Keywords Vitamin D, dental implant failure
ID# 3441
Date of submission 12/03/2020
E-mail Kataoka@livemail.uthscsa.edu
Author Satoru Kataoka, DDS
Co-author(s) Brandon M. Wilburn, DMD
Co-author(s) e-mail wilburnb1@livemail.uthscsa.edu
Faculty mentor Dr. Robert Taft
Faculty mentor e-mail Taftr@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
None available
Comments and Evidence-Based Updates on the CAT
None available