Title Tooth Loss Is More Prevalent in Adults with Major Depressive Disorder
Clinical Question In patients with major depressive disorder is tooth loss more prevalent than in people without it?
Clinical Bottom Line In adults with current depression, tooth loss is more prevalent than in adults without current depression. This is supported by a cross-sectional study that analyzed the association between tooth loss and current depression after adjusting for confounding factors in 80,486 adults using logistic regression analyses.
Best Evidence  
PubMed ID Author / Year Patient Group Study type
(level of evidence)
21883356 Okoro/2012 80,486 adults in 16 states who participated in the Behavioral Risk Factor Surveillance System to evaluate current depression, lifetime diagnosis of depression, and lifetime diagnosis of anxiety.Cross Sectional Study
Key resultsThe results showed that, after adjusting for confounding factors like sociodemographic factors and the use of oral health services, the odds of being in the 1-5 missing teeth, 6-31 missing teeth, or all-teeth-missing categories versus 0 teeth removed are higher in adults with current depression than adults without depression (adjusted odds ratio [AOR] = 1.35; 95% CI=1.14–1.59; AOR = 1.83; 95% CI=1.51–2.22; and AOR = 1.44; 95% CI=1.11–1.86, respectively).
Evidence Search ("depressive disorder"[MeSH Terms] OR ("depressive"[All Fields] AND "disorder"[All Fields]) OR "depressive disorder"[All Fields] OR "depression"[All Fields] OR "depression"[MeSH Terms]) AND ("tooth loss"[MeSH Terms] OR ("tooth"[All Fields] AND "loss"[All Fields]) OR "tooth loss"[All Fields])
Comments on
The Evidence
Validity: The cross-sectional study showed significant correlations between major depressive disorder and tooth loss. There were a large number of subjects in the study, which strengthens the evidence. One thing that might be a source of bias is that the survey was only conducted in 16 states, so there might be some non-coverage bias. Also, all the data obtained for the study was done via questionnaires, which could be a source of recall or response bias.
Applicability For patients with current depression there is a higher prevalence of tooth loss; therefore it is important to try and identify these patients and manage them appropriately to decrease the risk of tooth loss.
Specialty (General Dentistry) (Oral Surgery) (Interprofessional CATs)
Keywords depression; tooth loss
ID# 3054
Date of submission 04/04/2016
E-mail salinaso@livemail.uthscsa.edu
Author Omar Salinas
Co-author(s) e-mail
Faculty mentor John P. Hatch, PhD
Faculty mentor e-mail hatch@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
None available
Comments and Evidence-Based Updates on the CAT
None available