Title Parathyroid Hormone (PTH) Increases The Rate of Orthodontic Tooth Movement in Rats
Clinical Question For patients undergoing orthodontic treatment, could Parathyroid Hormone (PTH) administration during orthodontic therapy, rather than traditional orthodontic therapy, result in an increased orthodontic tooth movement?
Clinical Bottom Line Parathyroid Hormone (PTH) does increase the rate of orthodontic tooth movement in rats. Human studies have yet to be conducted due to the limitation in a stable and effective method of delivery.
Best Evidence  
PubMed ID Author / Year Patient Group Study type
(level of evidence)
11023269Soma/200056 Male Wistar rats. 8 were assigned to each of 7 treatment groups where traditional therapy was performed in one group and different methods of PTH administration was performedAnimal Study
Key resultsInjection of Parathyroid Hormone (PTH) at 1 ug/400g BW resulted in an increase of 1.6x compared to the control group over a period of 12 days.
24075660Li/201360 Male Wistar rats randomly divided into two groups. One group received a 4ug/100g BW dose of PTH over a 12 day period. The control received a vehicle injection devoid of PTH.Animal Study
Key resultsThe effect of intermittent Parathyroid Hormone (PTH) administration over the course of 12 days increased the bone turnover rate, which resulted in the acceleration of tooth movement by 10%.
Evidence Search pth[All Fields] AND ("orthodontics"[MeSH Terms] OR "orthodontics"[All Fields]) AND ("tooth movement"[MeSH Terms] OR ("tooth"[All Fields] AND "movement"[All Fields]) OR "tooth movement"[All Fields]) AND ("parathyroid hormone"[MeSH Terms] OR ("parathyroid"[All Fields] AND "hormone"[All Fields]) OR "parathyroid hormone"[All Fields]) AND accelerated[All Fields]
Comments on
The Evidence
These studies only showed the short-term 12-day response to treatment with Parathyroid Hormone (PTH) and didn’t display the effects that would be produced had the study gone further. When a reliable method of long-term delivery that can sustain adequate levels of PTH in both quantity and quality, human studies ought to be conducted in order to observe their effect on the human dentition. Also, although PTH showed significant acceleration in tooth movement it would be interesting to observe the effect that other agents, that have shown a positive effect on the acceleration of tooth movement (Thyroid hormone, prostaglandin, etc.), could have when used in combination with PTH administration.
Applicability If Parathyroid Hormone (PTH) proves to be safe for use in humans and a reliable method of delivery can be achieved, the applicability could encompass all patients undergoing orthodontic treatment. Since the dosage would be minimal due to the localized delivery method, there should be no adverse systemic effects – this aspect should also be studied during human trials.
Specialty (Orthodontics)
Keywords Orthodontics PTH parathyroid hormone accelerated acceleration tooth movement
ID# 2931
Date of submission 10/15/2015
E-mail alsharifk@uthscsa.edu
Author Khaled AlSharif, DDS
Co-author(s) e-mail
Faculty mentor Peter Gakunga, BDS, MS, PhD
Faculty mentor e-mail gakunga@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
None available
Comments and Evidence-Based Updates on the CAT
None available