Title Thymoquinone Has Anti-Tumor Effects on Squamous Cell Carcinoma in Mice
Clinical Question Does thymoquinone have anti-tumor effects in patients with oral squamous cell carcinoma?
Clinical Bottom Line Thymoquinone has not been shown to be effective against oral squamous cell carcinoma in humans. The drug, however, has been shown to have anti-tumor effects against squamous cell carcinoma in mouse models.
Best Evidence  
PubMed ID Author / Year Patient Group Study type
(level of evidence)
17080016Ivankovic/2006In vivo: cell lines; in vitro: mouse tumor modelsLaboratory study
Key resultsThymoquinone was shown to have good antitumor activity on both squamous cell carcinoma (SCC VII) and fibrosarcoma (FsaR) cells in mice. The therapeutic effect achieved was 49% against SCC VII and 33% against FsaR.
Evidence Search Squamous Cell Carcinoma AND Thymoquinone
Comments on
The Evidence
This study is valid because the control and test groups were the same at the start of experiment and they were treated the same. There does not seem to be any conflict of interest by the authors. The authors compared the tumor response to thymoquinone and thymohydroquinone of the test groups to the control group that received no treatment.
Applicability The significant anti-tumor effects demonstrated in these pre-clinical mouse xenograft models provide rationale to translate this finding to a clinical application for oral cancer patients. Importantly, phase I clinical studies of thymoquinone demonstrated that it is non-toxic to humans. Therefore, thymoquinone may provide a new therapy for oral cancer patients.
Specialty (Oral Medicine/Pathology/Radiology) (Oral Surgery)
Keywords Carcinoma, Squamous Cell, Tumor, Mice, Drug Therapy, Thymoquinone
ID# 2784
Date of submission 12/05/2014
E-mail Leed7@uthscsa.edu
Author Debbie R. Lee, DDS
Co-author(s) e-mail
Faculty mentor Cara Gonzales, PhD, DDS
Faculty mentor e-mail gonzalesc5@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
None available
Comments and Evidence-Based Updates on the CAT
None available