Title Osteoporosis Has No Significant Impact On Dental Implant Osseointegration
Clinical Question Does osteoporosis affect the success rates of osseointegration of dental implants in adult patients?
Clinical Bottom Line Adult patient with osteoporosis show no significant increase in dental implant osseointegration failures as compared to adults without osteoporosis.
Best Evidence  
PubMed ID Author / Year Patient Group Study type
(level of evidence)
23940794Chen/20131142 human adultsMeta-Analysis
Key resultsThe meta-analysis reports a lack of impact of osteoporosis on the failures of dental implant. There was a direct influence of a patients osteoporosis on the outcome of dental implants, but it was not significant (n = 4; RR = 1.09; 95% CI, 0.79-1.52).
19014161Holahan/2008Human AdultsCase Control Study
Key resultsA diagnosis of osteoporosis did not contribute to increased risk of implant failure. Patients with osteoporosis or osteopenia were not more inclined to dental implant failures than other patients without these particular clinical diagnosis's "(HR = 1.14, 95% CI = 0.50 to 0.60, P = .76 and HR = 0.98, 95% CI = 0.40 to 2.42, P = .97, respectively)."
Evidence Search “Osteoporosis AND Dental Implants”, “Osteoporosis AND Dental Implant Success”
Comments on
The Evidence
In the meta-analysis by Chen and colleagues, a comprehensive and detailed search for relevant trials was performed and individual studies were assessed for their validity. There were a total of 4 studies assessing dental implant failure and osteoporosis. There were 1141 patients over 4 trials with 3070 total implants used in the data. The follow-up time was sufficient for 3 of the 4 trials, and varied from study to study with the shortest duration at 9 months and the longest duration at 10 years. There was a meta-analysis conducted. In the case-controlled study by Holahan and colleagues, a comprehensive and detailed trial was performed. Osteoporotic status was defined on the basis of bone mineral density score utilizing World Health Organization criteria. There were a total of 746 patients involved totaling 3,224 implants used in the data. The 5 year follow-up time for the patients was adequate for the study. There was no meta-analysis conducted.
Applicability These results are applicable to adult patients who have osteoporosis and are considering dental implant therapy.
Specialty (General Dentistry) (Oral Surgery) (Periodontics) (Prosthodontics)
Keywords Dental implant, implant failure, osteoporosis, osteopenia
ID# 2645
Date of submission 03/31/2014
E-mail buchwaldm@livemail.uthscsa.edu
Author Max Buchwald
Co-author(s) e-mail
Faculty mentor Barbara MacNeill, DMD
Faculty mentor e-mail macneill@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
None available
Comments and Evidence-Based Updates on the CAT
None available