Title The Supplemental Use of Chlorhexidine with Scaling and Root Planning Therapy, When Treating Diabetic Patients, does not Significantly Improve Periodontal Outcomes as Compared to Scaling and Root Planning Alone
Clinical Question For diabetic patients undergoing scaling and root planning periodontal therapy, does a combination therapy that includes Chlorhexidine significantly improve periodontal outcomes over scaling and root planning without chlorhexidine?
Clinical Bottom Line The use of Chlorhexidene in a combination therapy did not yield statistically significant results when compared to scaling and root planning therapy alone.
Best Evidence  
PubMed ID Author / Year Patient Group Study type
(level of evidence)
23305133 Santos/2013Subjects with poorly controlled type 2 diabetes and generalized chronic periodontitis.Randomized Controlled Trial
Key resultsAll clinical parameters, with and without chlorhexidine, improved at all time post-therapies markers for both groups (p < 0.05). There were no significant differences between groups for any clinical parameters, and glycemic condition at any time-point (p > 0.05).
Evidence Search (“Diabetes Mellitus”[MeSH] AND “ Periodontitis”[All Fields] AND “chlorhexidine “All Fields])
Comments on
The Evidence
The randomized controlled clinical trial added chlorhexidine to its trials to test its efficacy. There is a need to conduct more studies among diabetic patients that show a greater numerical change in outcomes with a larger sample size to adequately observe a statistically significant change in diabetes glycemic parameters and periodontal disease.
Applicability The benefits of adding chlorhexidine to scaling and root planning therapy are not statistically significant enough to include it to the diabetic patient’s periodontal disease treatment.
Specialty (Public Health) (General Dentistry) (Periodontics) (Dental Hygiene)
Keywords Diabetes Mellitus, Chlorhexidine, Periodontal Therapy
ID# 2628
Date of submission 03/28/2014
E-mail Hemmat@livemail.uthscsa.edu
Author Peggah Hemmat
Co-author(s) e-mail
Faculty mentor Juanita Lozano-Pineda, DDS, MPH
Faculty mentor e-mail Pinedaj@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
None available
Comments and Evidence-Based Updates on the CAT
None available