Title Use of Corticosteroids Before the Extraction of Third Molars to Reduce Post-Operative Edema
Clinical Question Can pre-medication with corticosteroids help in reduction of edema, following extraction of third molars?
Clinical Bottom Line Pre-medication with corticosteroids when extracting third molars allows mild-moderate reduction in edema after surgery.
Best Evidence  
PubMed ID Author / Year Patient Group Study type
(level of evidence)
18718396Markiewwicz/200810 Clinical Trial Total patients 513Meta-Analysis, Research support (Non-US Gov)
Key resultsIn this study two Treatment groups were used, One receiving Corticosteroids (245 patients) before the extraction of Third molars & the second Control group(268 patients) with no pre-medication. Patients pre-medicated with Corticosteroids before the extraction of third Molar showed 0.6 mm less swelling than controls 1 to 3 days after surgery (P<0.001) and 0.5 mm less swelling than controls 4-7 days after surgery (P=0.03). Hence concluding that Pre-medication with CS when extracting third molars allows mild to moderate reduction in Edema up to 7 days post-operatively.
Evidence Search PubMed Search; “Corticosteroids” MeSH, “Edema” MeSH, “Third molar extractions” MeSH. “Swelling” MeSH.
Comments on
The Evidence
Patients represented the full spectrum of Third molar extracts studied. Criteria for the findings were explicit & credible. The diagnostic work-up was comprehensive and consistently applied. There was no mention on the Follow-up of the patients. The author was not found to have competing interests.
Applicability The study participants represented a full spectrum of Third Molar Extraction patients. The administration of Corticosteroids pre-operatively is Feasible in the surgical operatory.
Specialty (General Dentistry) (Oral Surgery)
Keywords Corticosteroids, edema, Extraction, Third Molars.
ID# 2561
Date of submission 08/16/2013
E-mail Faiza.Baig@ucdenver.edu
Author Faiza Baig
Co-author(s) e-mail
Faculty mentor Ronald N. Brown, DDS
Faculty mentor e-mail Ronald.Brown@ucdenver.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
None available
Comments and Evidence-Based Updates on the CAT
None available