Title Amelxanox Tablets Is More Effective Than Placebo In Reducing Pain And Ulceration Size In Treatment Of Patients With Recurrent Minor Aphthous Stomatitis
Clinical Question Does Amlexanox treatment in a patient with recurrent minor aphthous stomatitis decrease perceived pain and duration of ulceration compared to placebo?
Clinical Bottom Line For patients with recurrent minor aphthous stomatitis Amelxanox tablets is more effective than placebo in reducing pain and ulceration size.
Best Evidence  
PubMed ID Author / Year Patient Group Study type
(level of evidence)
16997114Liu/2006212 Patients with minor aphthous stomatitis. Median age 34.Double blind RCT
Key resultsMean ulcer size in the Amelxanox group was significantly smaller compared to the control group on day 6 (p<.001). The Amlexanox group also presented with a significantly greater efficacy index on day 6, for the reduction of pain (P<.05) and ulcer size (P <.001).
Evidence Search "Stomatitis, Aphthous/therapy"[Mesh] AND "amlexanox"[Supplementary Concept]
Comments on
The Evidence
In Lui’s double blind randomized controlled trial, 212 patients were given Amelxanox for six days. Patients were instructed to self administer Amelxanox tablets 4 times a day, but there is no comments whether patients were compliant with dosage recommendations. Patients had less than 5mm ulcers and were assessed on pain and ulcer size on days 4 and 6.
Applicability Amelxanox treatment was accepted well by patients with minor aphthous stomatitis. This treatment can be used patients ranging from early teens to the elderly.
Specialty (General Dentistry) (Dental Hygiene)
Keywords Aphthous Stomatitis
ID# 2452
Date of submission 03/01/2013
E-mail mcphersonj@livemail.uthscsa.edu
Author James McPherson
Co-author(s) e-mail
Faculty mentor John Gildersleeve, DDS
Faculty mentor e-mail GILDERSLEEV@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
None available
Comments and Evidence-Based Updates on the CAT
None available