Title |
Vitamin E in Combination With Aspirin Can Pose Potential Postoperative Bleeding |
Clinical Question |
In a patient undergoing oral surgery, can vitamin E in combination with aspirin pose increased risk of postoperative bleeding? |
Clinical Bottom Line |
Both articles indicate the enhanced anti-platelet effect of aspirin in combination with vitamin E. |
Best Evidence |
|
PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
11940487 | Celestini/2002 | Healthy Human (blood) taking no medication. | In vitro study | Key results | The anti-platelet aggregation effect of acetylsalicylic acid was enhanced in presence of vitamin E, by increasing the NO(nitrous oxide) production 42 fold(P < 0.05). | 16011961 | Gonzalez-Correa/2005 | Whole blood from healthy male who had not taken any medication at least 15 days prior. | In vitro Study | Key results | Vitamin E(50 and 100 µM) inhibited the aggregation of platelets in aspirin(2-20 µg/mL) treated platelets. The presence of Vitamin E in combination with aspirin required a higher collagen concentration to receive 50% maximal platelet activation. “(7.77±0.38 µg/mL and 10.82±0.46 µg/mL, respectively versus 4.25±1.03 µg/mL of untreated aspirinated-platelets; p< 0.0001)” | |
Evidence Search |
(("Aspirin"[Mesh]) AND "Vitamin E"[Mesh]) AND "Blood Platelets"[Mesh] |
Comments on
The Evidence |
The strength of evidence found in these articles were not significantly valid. None had an obvious competing interest in their trial. None of the articles conducted meta-analysis. |
Applicability |
It is imperative for Clinician's to be aware and take in to account the possible adverse effect of patients that are taking Vitamin E in combination with aspirin. |
Specialty |
(Oral Medicine/Pathology/Radiology) (Endodontics) (General Dentistry) (Oral Surgery) (Periodontics) (Dental Hygiene) |
Keywords |
Vitamin E, Acetylsalicylic acid, collagen, antiplatelet aggregation
|
ID# |
2440 |
Date of submission |
04/01/2013 |
E-mail |
Heydaris3@livemail.uthscsa.edu |
Author |
Soulmaz Heydari |
Co-author(s) |
|
Co-author(s) e-mail |
|
Faculty mentor |
Gregory Spackman, DDS, MBA |
Faculty mentor e-mail |
spackman@uthscsa.edu |
|
|
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
None available | |
 |
Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
None available | |