Title Articane Provides Longer Lasting Anesthesia in Buccal Infiltration Compared to Lidocaine on Healthy Teeth
Clinical Question In a patient undergoing buccal infiltration is articaine longer lasting compared to lidocane on healthy teeth?
Clinical Bottom Line For patients undergoing buccal infiltration, articane is longer lasting than lidocaine. This is supported by a meta-analysis in which articaine outperformed lidocaine by a clinically significant margin.
Best Evidence  
PubMed ID Author / Year Patient Group Study type
(level of evidence)
21531931Brandt/201113 studies (269 patients)Meta-Analysis
Key resultsArticaine 4% 1:100,000 epi proves to be 3.81 times longer lasting in buccal infiltration on healthy teeth than lidocaine 2% 1:100,000 epi with a 95% Cl.
Evidence Search (("Carticaine"[Mesh]) AND "Lidocaine"[Mesh]) AND "Anesthesia"[Mesh]
Comments on
The Evidence
Brandt and colleagues analyzed a set of randomized controlled trials and systematic reviews, with a total of 269 patients, comparing anesthetic length of both articaine 4% 1:100,000 epi and lidocaine 2% 1:100,000 epi. Lidocaine was used as the gold standard. Compilation of the article titles was done electronically, which resulted in elimination of any source of bias. The qualities of all trials chosen were evaluated by considering randomization, and both description and number of patient losses. No competing interests were found.
Applicability Due to articaine‘s extensive availability and its similar price to lidocaine, it presents itself as a practical option for routine dental practices. However, its effect on inflamed teeth has not been proven.
Specialty (General Dentistry)
Keywords Articaine, Lidocaine, Anesthesia.
ID# 2437
Date of submission 03/01/2013
E-mail benavidesr@livemail.uthscsa.edu
Author Roberto Benavides
Co-author(s) e-mail
Faculty mentor John Gildersleeve, DDS
Faculty mentor e-mail gildersleev@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
None available
Comments and Evidence-Based Updates on the CAT
None available