ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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Title Disinfection By Triple Antibiotic Paste During Regenerative Endodontic Treatment
Clinical Question In treating a patient with an immature permanent tooth with pulpal necrosis, will a regenerative endodontic treatment with disinfection by a triple antibiotic paste compared with calcium hydroxide paste, or formocresol paste produce better results in root development?
Clinical Bottom Line Treating the root canal with a triple antibiotic paste produces better results in root development than calcium hydroxide or formocresol treatment. (See Comments on the CAT below)
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 19801227Bose/2009 48 cases of regenerative endo and a control of 40Case Series
Key resultsThe author’s conclusions are as stated: “The results showed regenerative endodontic treatment with triple antibiotic paste (P < .001) and Ca(OH)(2) (P < .001) produced significantly greater increases in root length than either the MTA apexification or NSRCT control groups. The triple antibiotic paste produced significantly greater differences in root wall thickness than either the Ca(OH)(2) or formocresol groups (P < .05 for both).”
Evidence Search Search regenerative endodontics
Comments on
The Evidence
This study was a case series where the groups were similar at the start and had a greater than 80% completion. The groups were the same and had adequate follow-up. This study was not double blind and had adequate compliance with unlikely recall bias and no competing interests.
Applicability These subjects most likely represent patients that would be seen by an endodontist or pediatric dentist. This treatment may not be applicable in a general dentist setting.
Specialty/Discipline (Endodontics) (Pediatric Dentistry)
Keywords Immature teeth, regenerative endodontics, retrospective studies, revascularization
ID# 827
Date of submission: 03/30/2011spacer
E-mail ericksonjm@livemail.uthscsa.edu
Author Jay Erickson
Co-author(s)
Co-author(s) e-mail
Faculty mentor/Co-author Kenneth Hargreaves, DDS, PhD
Faculty mentor/Co-author e-mail HARGREAVES@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
post a rationale
None available
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Comments on the CAT
(FOR PRACTICING DENTISTS' and/or FACULTY COMMENTS ON PUBLISHED CATs)
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by Vanessa Chrepa (San Antonio, TX) on 07/08/2012
This is still the study with the strongest evidence on this clinical question. There are two more resent studies both on rats showed that triple antibiotic paste is biocompatible and improves root development. (2012) PMID: 22152628 and (2011) PMID: 21763896 (2011).
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