ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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Title Oral Patch Treatment for Xerostomia
Clinical Question In post-chemo- and radio-therapy patients, are OraMoist Oral Patches as or more effective in relieving xerostomia symptoms when compared to other products such as mouth rinses or oral sprays?
Clinical Bottom Line Though no studies have been conducted to compare OraMoist Oral Patches with other products such as mouth rinses or other oral medications, there is no apparent benefit to using OraMoist Patches when compared to a placebo muco-adhesive patch, though both improve salivary flow. (See Comments on the CAT below)
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 20884928Kerr/201027 patients with dry mouthRandomized double-blind crossover trial
Key resultsNo difference when compared to placebo muco-adhesive patch, both displayed increase in salivary flow within 60 minutes following application. Over a span of one and two weeks, patient baseline salivary flow rate also increased with no reported adverse affects.
Evidence Search "Xerostomia/therapy"[Mesh] AND oramoist ...view in PubMed
Comments on
The Evidence
The patient pool could be larger and comparisons to other products such as mouth rinses and oral drugs could be made to further determine the effectiveness muco-adhesive patches in general. If simple adhesion of a non-medicated disk to the mucosal surface can elicit an adequate response to relieve xerostomia symptoms, it would allow patients to eliminate the risk of drug interactions and side effects to more conventional xerostomia treatment methods.
Applicability More studies need to be conducted to include other xerostomia treatments in order to fully determine the effectiveness of OraMoist Patches.
Specialty/Discipline (Public Health) (General Dentistry)
Keywords Xerostomia Treatment, Mucoadhesive, OraMoist
ID# 817
Date of submission: 03/24/2011spacer Revised: 04/30/2012
E-mail LaiJT@livemail.uthscsa.edu
Author Justin Lai
Co-author(s)
Co-author(s) e-mail
Faculty mentor/Co-author Howard Dang, PhD
Faculty mentor/Co-author e-mail DANG@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
post a rationale
None available
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Comments on the CAT
(FOR PRACTICING DENTISTS' and/or FACULTY COMMENTS ON PUBLISHED CATs)
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by Luke Tibbitts & Mohamad Alhadlaq (Victoria, TX & Riyadh) on 06/25/2014
After conducting a PubMed search on June 25, 2014, no new studies were found on this topic. Evidence used in this CAT is up to date and could be applied in daily practice.
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