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| Title |
Dietary Bioflavonoid Supplementation and Dental caries |
| Clinical Question |
In an adult population will dietary bioflavonoid supplementation reduce dental caries compared to placebo? |
| Clinical Bottom Line |
Early research on bioflavonoid supplementation has shown significant reduction of dental caries but more research is needed. (See Comments on the CAT below) |
| Best Evidence |
(you may view more info by clicking on the PubMed ID link) |
| PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
| #1) 18158843 | Wood / 2007 | 40 male albino rats | Animal Study | | Key results | Dietary bioflavonoid supplementation with rutin, quercetin, and naringin showed a statistically significant effect on decreasing dental caries versus placebo in rats. | | #2) 20109485 | Koyama Y/2010 | 25,078 persons from Ohsaki Cohort 2006 Study in Japan | Cohort study | | Key results | The consumption of 1 or more cups of green tea per day was significantly associated with decreased odds for tooth loss. In men, the multivariate-adjusted odd ratios were 1.00 (reference) for less than 1 cup/day, 0.82 (95% CI, 0.74-0.91) for 1-2 cups/day, 0.82 (95% CI, 0.73-0.92) for 3-4 cups/day, and 0.77 (95% CI, 0.66-0.89) for greater or equal to 5 cups/day. The data for women was very similar. | | #3) 20234135 | Koo H/2010 | Sprague-Dawley rats | Animal Study | | Key results | Proanthocyanidins (PAC) in cranberry extracts significantly reduced smooth-surface caries and sulcal surface caries in rats. | |
| Evidence Search |
Search "Dental Caries Susceptibility"[Mesh]Search "Dental Caries"[Mesh]Search "Flavonoids"[Mesh] |
Comments on
The Evidence |
The evidence presented in these studies appears valid and has demonstrated the potential value of bioflavonoid supplementation in helping to prevent future dental caries. However, randomized controlled trials comparing bioflavonoids to placebo are still needed. Because of the types of studies currently performed, more research is required before this should be applied in the dental practice. |
| Applicability |
The evidence presented in these studies is not applicable at this time because two of the studies are animal studies involving rats, and one is a longitudinal study involving only a Japanese population. |
| Specialty/Discipline |
(Public Health) (General Dentistry) (Dental Hygiene) |
| Keywords |
caries, Nutrition, Bioflavonoids
|
| ID# |
804 |
| Date of submission: |
04/04/2011 |
| E-mail |
greenb@livemail.uthscsa.edu |
| Author |
Benjamin Green |
| Co-author(s) |
|
| Co-author(s) e-mail |
|
| Faculty mentor/Co-author |
Georgiana S. Gross, MPH |
| Faculty mentor/Co-author e-mail |
GROSSG@uthscsa.edu |
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
post a rationale |
| None available | |
|
Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
post a comment |
by Jeff Adcock, Aimee Chung (San Antonio, TX) on 10/03/2014
A PubMed search was performed Sept. 2014 with the MeSH Terms “dental caries” and “bioflavonoids.” A more recent RCT publication was found: Tao 2013, PMID: 24579286. This RCT further supports the conclusions of this CAT. | |
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