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Title Dietary Bioflavonoid Supplementation and Dental caries
Clinical Question In an adult population will dietary bioflavonoid supplementation reduce dental caries compared to placebo?
Clinical Bottom Line Early research on bioflavonoid supplementation has shown significant reduction of dental caries but more research is needed. (See Comments on the CAT below)
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 18158843Wood / 200740 male albino ratsAnimal Study
Key resultsDietary bioflavonoid supplementation with rutin, quercetin, and naringin showed a statistically significant effect on decreasing dental caries versus placebo in rats.
#2) 20109485Koyama Y/201025,078 persons from Ohsaki Cohort 2006 Study in JapanCohort study
Key resultsThe consumption of 1 or more cups of green tea per day was significantly associated with decreased odds for tooth loss. In men, the multivariate-adjusted odd ratios were 1.00 (reference) for less than 1 cup/day, 0.82 (95% CI, 0.74-0.91) for 1-2 cups/day, 0.82 (95% CI, 0.73-0.92) for 3-4 cups/day, and 0.77 (95% CI, 0.66-0.89) for greater or equal to 5 cups/day. The data for women was very similar.
#3) 20234135 Koo H/2010Sprague-Dawley ratsAnimal Study
Key resultsProanthocyanidins (PAC) in cranberry extracts significantly reduced smooth-surface caries and sulcal surface caries in rats.
Evidence Search Search "Dental Caries Susceptibility"[Mesh]Search "Dental Caries"[Mesh]Search "Flavonoids"[Mesh]
Comments on
The Evidence
The evidence presented in these studies appears valid and has demonstrated the potential value of bioflavonoid supplementation in helping to prevent future dental caries. However, randomized controlled trials comparing bioflavonoids to placebo are still needed. Because of the types of studies currently performed, more research is required before this should be applied in the dental practice.
Applicability The evidence presented in these studies is not applicable at this time because two of the studies are animal studies involving rats, and one is a longitudinal study involving only a Japanese population.
Specialty/Discipline (Public Health) (General Dentistry) (Dental Hygiene)
Keywords caries, Nutrition, Bioflavonoids
ID# 804
Date of submission: 04/04/2011spacer
E-mail greenb@livemail.uthscsa.edu
Author Benjamin Green
Co-author(s) e-mail
Faculty mentor/Co-author Georgiana S. Gross, MPH
Faculty mentor/Co-author e-mail GROSSG@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
post a rationale
None available
Comments and Evidence-Based Updates on the CAT
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by Jeff Adcock, Aimee Chung (San Antonio, TX) on 10/03/2014
A PubMed search was performed Sept. 2014 with the MeSH Terms “dental caries” and “bioflavonoids.” A more recent RCT publication was found: Tao 2013, PMID: 24579286. This RCT further supports the conclusions of this CAT.

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