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Title |
Doubtful Link Between Hepatitis C Infection & Presence Of Hyposalivation |
Clinical Question |
Is there a relationship between development of xerostomia/hyposalivation & the presence of salivary hepatitis C viral RNA? |
Clinical Bottom Line |
There does not seem to be a link between the presence of Hepatitis C viral RNA in saliva as a cause of hyposalivation or xerostomia in patients with chronic hepatitis C infection, but evidence specific to clinical question is limited. (See Comments on the CAT below) |
Best Evidence |
(you may view more info by clicking on the PubMed ID link) |
PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
#1) 20451844 | Soraya de Matos/2010 | Patients with confirmed diagnosis of chronic hepatitis C infection | Case control | Key results | While there appears to be an increase in incidence of hyposalivation/xerostomia in patients with chronic Hepatitis C infection, there does not appear to be a correlation between hyposalivation and detection of HCV RNA in saliva. | |
Evidence Search |
("Hepatitis C"[Mesh]) AND "Xerostomia"[Mesh] ...view in PubMed |
Comments on
The Evidence |
A PCR test was used as the gold standard to detect the presence of HCV RNA in patients. Saliva during non-stimulated salivary flow was collected over a 3-minute period in these patients. This same standard was applied to all patients in the sample pool. |
Applicability |
This type of study could be applied in practice. These tests are available to clinicians. Determination of the likelihood that patients with Hepatitis C infection will develop hyposalivation may allow a clinician to more appropriately treat these patients and educate them with respect to potential development of hyposalivation and subsequent disease. |
Specialty/Discipline |
(Oral Medicine/Pathology/Radiology) (General Dentistry) (Basic Science) |
Keywords |
Hepatitis C, hyposalivation, xerostomia
|
ID# |
750 |
Date of submission: |
03/29/2011 |
E-mail |
tunnell@livemail.uthscsa.edu |
Author |
John Tunnell |
Co-author(s) |
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Co-author(s) e-mail |
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Faculty mentor/Co-author |
Geza Terezhalmy, DDS |
Faculty mentor/Co-author e-mail |
TEREZHALMY@uthscsa.edu |
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
post a rationale |
None available | |
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Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
post a comment |
by Tyler Martini, Michael Young, Susie DeKoch (San Antonio, Texas) on 01/06/2014 A PubMed search on xerostomia/hyposalivation and hepatitis C on January 2014 found limited related evidence. There was a more recent publication, PubMed ID 22489018 Maryam, 2012. This case-control study further supports the conclusions of this CAT. | |
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