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Title Evidence supports that toothpaste with arginine, calcium carbonate and fluoride is effective at treating dentin hypersensitivity
Clinical Question In treating patients with dentin hypersensitivity, is there a better therapeutic treatment for reducing hypersensitivity when compared to fluoride alone?
Clinical Bottom Line Toothpaste with arginine, calcium carbonate and fluoride was more effective at immediate relief of dentin hypersensitivity than fluoride alone. (See Comments on the CAT below)
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 19831165Nathoo/2009One-hundred and twenty-five subjects from the Piscataway, New Jersey, USA area who presented with two hypersensitive teeth based on tactile and air blast hypersensitivity scores.Randomized Controlled Trial
Key resultsThe 8.0% arginine toothpaste group showed statistically significant (p < 0.05) reductions in dentin hypersensitivity on both tactile and air blast hypersensitivity scores immediately after direct application. Compared to the control toothpaste groups, the 8.0% arginine group showed statistically significant (p < 0.05) reductions in sensitivity after three days of twice-daily regular tooth brushing.
Evidence Search Evidence Search: Search Most Recent Queries Time Result#17Search ("Dentin Sensitivity"[Mesh] AND "Dentin Desensitizing Agents"[Mesh]) AND "Therapeutics"[Mesh] 23:21:25 5
Comments on
The Evidence
This study, a RCT of 125 patients, compared treatment with a toothpaste containing 8% arginine, calcium carbonate, and 1450 ppm fluoride with toothpaste containing 1450 ppm fluoride, in patients with dentin sensitivity. Recall bias was unlikely and follow-up was good, and validity was strong because patients were similar at the start and were treated the same.
Applicability The results in the best evidence can help me in my practice to be able to confidently recommend a type of desensitizing treatment for my patients. From this evidence, I will be able to say that the new toothpaste with arginine is helpful in immediately reducing pain from sensitivity.
Specialty/Discipline (General Dentistry) (Dental Hygiene)
ID# 594
Date of submission: 03/25/2010spacer
E-mail chitwood@livemail.uthscsa.edu
Author Aubrey Kendall Chitwood
Co-author(s) e-mail
Faculty mentor/Co-author E. Penn Jackson, DDS
Faculty mentor/Co-author e-mail JacksonEP@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
post a rationale
None available
Comments and Evidence-Based Updates on the CAT
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by David Wallach (San Antonio, TX) on 04/24/2012
I conducted a PubMed search on this topic on 4/22/2012. The information provided in this CAT appears to be up to date. It also refers to the highest level of evidence.

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