ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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Title Alleviation of Xerostomia Symptoms with the Use of Biotene Products
Clinical Question In a patient with xerostomia, is the uses of Biotene products more effective than no treatment in alleviating the symptoms of xerostomia?
Clinical Bottom Line The use of oral gel and mouthrinse does improve symptoms related to xerostomia in elderly patients and those who have undergone radiotherapy. (See Comments on the CAT below)
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 18194332Gil-Montoya /2008ElderlyRandomized, double blind
Key resultsThe variables used to compare the effects of mouthwash and oral gel against a placebo for the 20 elderly subjects with xerostomia include subjective dry mouth sensation (p=0.414), the severity of discomfort assessed by means of a visual analogical scale (p=0.679), the Oral Health Impact Profile (p=0.022), the presence of signs and symptoms of dry mouth (p=0.052), sialometry (p=0.226) and candida albicans culture (p=0.372). Even though mouthwash and oral gel improved some aspects of dry mouth, the presence of placebo effect cannot be ignored.
#2) 16098116Shahdad/2005Adult with radiotherapy xerostomiaRandomized, double blind
Key resultsIn 20 patients with post-radiotherapy xerostomia, Biotene Oralbalance was proven to be less superior to Bioxtra in its improvement of dry mouth, speech, and taste (P<0.05). However, based on the visual analogue scales, there were no significant differences between the two products (P>0.05). In conclusion, both were found effective.
#3) 10789961Warde/2000Adults with radical radiation therapy xerostomiaClinical Study
Key resultsAfter two months of treatment for the twenty-eight patients involved in the study, 15 (54%) reported improvement in dryness while 10 (36%) reported major improvement. For ability to eat normally, 46% reported improvement while 25% reported major improvement. 17 (61%) patients reported improvement in oral discomfort while 12 (43%) reported major improvement. Results suggest that radiation-induced xerostomia symptoms can be improved with the use of Biotene products.
Evidence Search Clinical Trial, Limits: Randomized Controlled Trial, Limits: English, Systematic Reviews, Meta-Analysis, EnglishSearch "Biotene "[Substance Name]Search "Xerostomia"[Mesh]
Comments on
The Evidence
The need for further study and stronger evidence in the improvement of xerostomia with the use of Biotene products is quite evident.
Applicability The results to these studies are mainly applicable for patients who have xerostomia because of old age or radiotherapy. Recommending the use of Biotene products is quite feasible because the focus of the studies represent a large patient pool and the non-invasive nature of the treatment.
Specialty/Discipline (General Dentistry) (Restorative Dentistry)
Keywords Xerostomia, Biotene
ID# 585
Date of submission: 04/01/2010spacer
E-mail Hoangv@livemail.uthscsa.edu
Author Vi Linh Hoang
Co-author(s)
Co-author(s) e-mail
Faculty mentor/Co-author Howard Dang, PhD
Faculty mentor/Co-author e-mail DANG@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
post a rationale
None available
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Comments on the CAT
(FOR PRACTICING DENTISTS' and/or FACULTY COMMENTS ON PUBLISHED CATs)
post a comment
by Christopher Lewis, Katie Bemis, Derrick LIn (San Antonio, TX) on 01/07/2013
Currently, there is no new research published on the topic. Given that most studies show inconclusive evidence for Biotene’s improvement on xerostomia, we agree with the CAT that more evidence is needed. We also agree that Biotene could still be a useful product due to its reported improvements clinically and its non invasive treatment.
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