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Title Sealants protect permanent premolars and molars from carious lesions
Clinical Question In a healthy adult or adolescent, do sealants reduce the incidence of carious lesions on permanent premolars and molars compared to no prophylactic treatment?
Clinical Bottom Line Application of pit and fissure sealants can reduce the occurrence of new carious lesions of permanent premolars and molars. (See Comments on the CAT below)
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 18843625Ahovuo-Saloranta/2008Children and adolescents under 20 years oldMeta-analysis
Key resultsThe following results apply to six studies comparing 2nd and 3rd generation resin sealants to “no sealant” controls. RR of 0.13, 0.22, 0.30, and 0.40 at 12, 24, 36, and 48-54 months follow up. 95% CI 0.09 to 0.20, 0.15 to 0.34, 0.22 to 0.40, 0.31 to 0.51, respectively.
Evidence Search “Pit and Fissure Sealants” [Mesh] AND “Dental Caries” [Mesh]
Comments on
The Evidence
The patient group of this study did not include adults, however, the results from this study are most likely applicable to adults as well since the results are based on permanent teeth and in a similar oral environment as a healthy adult. Currently, there is little research on treatment of sealants on adults.
Applicability Children, adolescents, and adults
Specialty/Discipline (General Dentistry)
Keywords sealant, carious lesion, permanent, molar, premolar
ID# 529
Date of submission: 02/23/2010spacer
E-mail riggsc@livemail.uthscsa.edu
Author Tim Jennings
Co-author(s) Chad Riggs
Co-author(s) e-mail
Faculty mentor/Co-author Barbara MacNeill, DMD
Faculty mentor/Co-author e-mail macneill@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
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None available
Comments on the CAT
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by Joseph Ryan (San Antonio, TX) on 04/10/2012
On 4-9-12, I reviewed the literature pertaining to this CAT and found that the article cited is indeed the most recent and relevant article regarding this PICO question.

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