ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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Title Treatment with acyclovir five times daily may reduce the duration of primary herpetic oral lesions
Clinical Question In children experiencing primary herpetic gingivostomatitis, does treatment with acyclovir, compared to no treatment, reduce the duration of oral lesions?
Clinical Bottom Line Treatment with acyclovir 5 times daily could reduce the duration of primary herpetic oral lesions. (See Comments on the CAT below)
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 18843726Nasser/2008Children and young adults < 25 years of age with a diagnosis of primary herpetic gingivostomatitisSystematic review
Key resultsTwo randomized controlled trials were included in this systematic review. One provided weak evidence that acyclovir is an effective treatment for primary herpetic gingivostomatitis. The results showed reduction in the number of individuals with oral lesions (risk ratio (RR) 0.10 (95% confidence interval (CI) 0.02 to 0.38)), new extraoral lesions (RR 0.04 (95% CI 0.00 to 0.65)), difficulty in eating (RR 0.14 (95% CI 0.03 to 0.58)), and drinking difficulties (RR 0.11 (95% CI 0.01 to 0.83)) after 8 days of treatment.
Evidence Search “Acyclovir”;[Mesh] AND &;”Stomatitis, Herpetic;[Mesh] AND Child;[Mesh]
Comments on
The Evidence
none
Applicability Children experiencing primary herpetic gingivostomatitis
Specialty/Discipline (General Dentistry)
Keywords Acyclovir, child, herpetic stomatitis, oral lesions, treatment
ID# 491
Date of submission: 01/07/2010spacer
E-mail riggsc@livemail.uthscsa.edu
Author Christi Wengler
Co-author(s) Chad Riggs
Co-author(s) e-mail
Faculty mentor/Co-author Lina M. Cardenas, DDS
Faculty mentor/Co-author e-mail
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
post a rationale
None available
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Comments on the CAT
(FOR PRACTICING DENTISTS' and/or FACULTY COMMENTS ON PUBLISHED CATs)
post a comment
by Leslie Jean (San Antonio, TX) on 04/09/2012
After performing a PubMed search on this topic on April 9, 2012, it has been found that the article presented in this CAT is still the most recent and highest level of evidence available.
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