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Title Vitamin D Supplementation May Reduce the Risk of Early Dental Implant Failure in Vitamin D-Deficient Patients
Clinical Question Does treatment of Vitamin D deficiency reduce the rate of early implant failure?
Clinical Bottom Line Vitamin D supplementation may reduce the risk of early dental implant failure in Vitamin D-deficient patients.
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 30443302Mangano/2018885 patients treated with 1,740 dental implantsRetrospective Cohort Study
Key resultsThis study did not demonstrate a significant relationship between low serum Vitamin D levels and early dental implant failure; however, there was a trend toward an increased incidence of early implant failure with lowering of serum vitamin D levels.
#2) 27888492Fretwurst/2016Two patientsCase report
Key resultsWith the limitation of this study, vitamin D deficient patients treated with vitamin D supplementation following early implant failure subsequently obtained successful implant placement.
#3) 25895415Bryce/2014One patientCase report
Key resultsOsseointegration of dental implants may fail in the presence of vitamin D deficiency.
Evidence Search “Dental implant vitamin D failure”
Comments on
The Evidence
The role of Vitamin D in the regulation of bone metabolism is well established. However, the potential effects of a Vitamin D deficiency in dentistry, and in the particular area of implant dentistry, is garnering clinical interest. Several modest case reports cite a potential association between low levels of serum vitamin D and failure of osseointegration of dental implants. These studies support the hypothesis that patients treated for a serum Vitamin D deficiency can be successfully rehabilitated with dental implants if the Vitamin D deficiency is corrected prior to implant placement. However, as this evidence is derived from case reports, and consequently represents a low quality of evidence, the results must be interpreted with a degree of caution. A larger, more robust, retrospective clinical study failed to establish a direct association between Vitamin D deficiency and early failure of dental implants. Nevertheless, the author did note a trend towards an increased incidence of early implant failure with lowering of serum vitamin D levels, which was not statistically significant (P=0.105). However, the study (n=885) also included a small number of patients (n=27) with severe Vitamin D deficiency (serum levels of vitamin D <10 ng/mL), who had an 11% early implant failure rate within the cohort. A direct association between early implant failure and serum Vitamin D level cannot be established; however, based on weak evidence there may be an association. Robust assessment of a patient’s medical history and general health is recommended prior to rehabilitation with dental implants.
Applicability Patients requiring dental implant treatment should have a comprehensive medical history taken, and where indicated be assessed for Vitamin deficiencies to improve overall health, and potentially increase the success of treatment.
Specialty/Discipline (General Dentistry) (Oral Surgery) (Periodontics) (Prosthodontics)
Keywords Vitamin D, dental implant failure
ID# 3441
Date of submission: 12/03/2020spacer
E-mail Kataoka@livemail.uthscsa.edu
Author Satoru Kataoka, DDS
Co-author(s) Brandon M. Wilburn, DMD
Co-author(s) e-mail wilburnb1@livemail.uthscsa.edu
Faculty mentor/Co-author Dr. Robert Taft
Faculty mentor/Co-author e-mail Taftr@uthscsa.edu
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