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| Title |
Vitamin D Supplementation May Reduce the Risk of Early Dental Implant Failure in Vitamin D-Deficient Patients |
| Clinical Question |
Does treatment of Vitamin D deficiency reduce the rate of early implant failure? |
| Clinical Bottom Line |
Vitamin D supplementation may reduce the risk of early dental implant failure in Vitamin D-deficient patients.
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| Best Evidence |
(you may view more info by clicking on the PubMed ID link) |
| PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
| #1) 30443302 | Mangano/2018 | 885 patients treated with 1,740 dental implants | Retrospective Cohort Study | | Key results | This study did not demonstrate a significant relationship between low serum Vitamin D levels and early dental implant failure; however, there was a trend toward an increased incidence of early implant failure with lowering of serum vitamin D levels. | | #2) 27888492 | Fretwurst/2016 | Two patients | Case report | | Key results | With the limitation of this study, vitamin D deficient patients treated with vitamin D supplementation following early implant failure subsequently obtained successful implant placement. | | #3) 25895415 | Bryce/2014 | One patient | Case report | | Key results | Osseointegration of dental implants may fail in the presence of vitamin D deficiency. | |
| Evidence Search |
“Dental implant vitamin D failure” |
Comments on
The Evidence |
The role of Vitamin D in the regulation of bone metabolism is well established. However, the potential effects of a Vitamin D deficiency in dentistry, and in the particular area of implant dentistry, is garnering clinical interest.
Several modest case reports cite a potential association between low levels of serum vitamin D and failure of osseointegration of dental implants. These studies support the hypothesis that patients treated for a serum Vitamin D deficiency can be successfully rehabilitated with dental implants if the Vitamin D deficiency is corrected prior to implant placement. However, as this evidence is derived from case reports, and consequently represents a low quality of evidence, the results must be interpreted with a degree of caution.
A larger, more robust, retrospective clinical study failed to establish a direct association between Vitamin D deficiency and early failure of dental implants. Nevertheless, the author did note a trend towards an increased incidence of early implant failure with lowering of serum vitamin D levels, which was not statistically significant (P=0.105). However, the study (n=885) also included a small number of patients (n=27) with severe Vitamin D deficiency (serum levels of vitamin D <10 ng/mL), who had an 11% early implant failure rate within the cohort.
A direct association between early implant failure and serum Vitamin D level cannot be established; however, based on weak evidence there may be an association. Robust assessment of a patient’s medical history and general health is recommended prior to rehabilitation with dental implants.
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| Applicability |
Patients requiring dental implant treatment should have a comprehensive medical history taken, and where indicated be assessed for Vitamin deficiencies to improve overall health, and potentially increase the success of treatment. |
| Specialty/Discipline |
(General Dentistry) (Oral Surgery) (Periodontics) (Prosthodontics) |
| Keywords |
Vitamin D, dental implant failure
|
| ID# |
3441 |
| Date of submission: |
12/03/2020 |
| E-mail |
Kataoka@livemail.uthscsa.edu |
| Author |
Satoru Kataoka, DDS |
| Co-author(s) |
Brandon M. Wilburn, DMD |
| Co-author(s) e-mail |
wilburnb1@livemail.uthscsa.edu |
| Faculty mentor/Co-author |
Dr. Robert Taft |
| Faculty mentor/Co-author e-mail |
Taftr@uthscsa.edu |
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
post a rationale |
| None available | |
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Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
post a comment |
| None available | |
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