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Title |
Parathyroid Hormone (PTH) Increases The Rate of Orthodontic Tooth Movement in Rats |
Clinical Question |
For patients undergoing orthodontic treatment, could Parathyroid Hormone (PTH) administration during orthodontic therapy, rather than traditional orthodontic therapy, result in an increased orthodontic tooth movement? |
Clinical Bottom Line |
Parathyroid Hormone (PTH) does increase the rate of orthodontic tooth movement in rats. Human studies have yet to be conducted due to the limitation in a stable and effective method of delivery. |
Best Evidence |
(you may view more info by clicking on the PubMed ID link) |
PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
#1) 11023269 | Soma/2000 | 56 Male Wistar rats. 8 were assigned to each of 7 treatment groups where traditional therapy was performed in one group and different methods of PTH administration was performed | Animal Study | Key results | Injection of Parathyroid Hormone (PTH) at 1 ug/400g BW resulted in an increase of 1.6x compared to the control group over a period of 12 days. | #2) 24075660 | Li/2013 | 60 Male Wistar rats randomly divided into two groups. One group received a 4ug/100g BW dose of PTH over a 12 day period. The control received a vehicle injection devoid of PTH. | Animal Study | Key results | The effect of intermittent Parathyroid Hormone (PTH) administration over the course of 12 days increased the bone turnover rate, which resulted in the acceleration of tooth movement by 10%. | |
Evidence Search |
pth[All Fields] AND ("orthodontics"[MeSH Terms] OR "orthodontics"[All Fields]) AND ("tooth movement"[MeSH Terms] OR ("tooth"[All Fields] AND "movement"[All Fields]) OR "tooth movement"[All Fields]) AND ("parathyroid hormone"[MeSH Terms] OR ("parathyroid"[All Fields] AND "hormone"[All Fields]) OR "parathyroid hormone"[All Fields]) AND accelerated[All Fields] |
Comments on
The Evidence |
These studies only showed the short-term 12-day response to treatment with Parathyroid Hormone (PTH) and didn’t display the effects that would be produced had the study gone further. When a reliable method of long-term delivery that can sustain adequate levels of PTH in both quantity and quality, human studies ought to be conducted in order to observe their effect on the human dentition. Also, although PTH showed significant acceleration in tooth movement it would be interesting to observe the effect that other agents, that have shown a positive effect on the acceleration of tooth movement (Thyroid hormone, prostaglandin, etc.), could have when used in combination with PTH administration. |
Applicability |
If Parathyroid Hormone (PTH) proves to be safe for use in humans and a reliable method of delivery can be achieved, the applicability could encompass all patients undergoing orthodontic treatment. Since the dosage would be minimal due to the localized delivery method, there should be no adverse systemic effects – this aspect should also be studied during human trials. |
Specialty/Discipline |
(Orthodontics) (Basic Science) |
Keywords |
Orthodontics PTH parathyroid hormone accelerated acceleration tooth movement
|
ID# |
2931 |
Date of submission: |
10/15/2015 |
E-mail |
alsharifk@uthscsa.edu |
Author |
Khaled AlSharif, DDS |
Co-author(s) |
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Co-author(s) e-mail |
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Faculty mentor/Co-author |
Peter Gakunga, BDS, MS, PhD |
Faculty mentor/Co-author e-mail |
gakunga@uthscsa.edu |
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
post a rationale |
None available | |
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Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
post a comment |
None available | |
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