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Title The Anticariogenic Benefit of Topical Ozone as a Management Technique for Active Carious Lesions Has Not Been Demonstrated
Clinical Question In patients with non-cavitated carious lesions, does the application of ozone to the surface of the carious lesions lead to a regression of the caries when compared to a placebo treatment?
Clinical Bottom Line The clinical use of ozone as an anticariogenic agent in non-cavitated lesions is unreliable based on current research. The lack of efficacy is supported by a systematic review of three randomized control trials. The use of ozone showed similar results to the placebo treatment.
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 15266519Rickard/20043 studies with 137 patients Systematic review of non-randomized trials
Key resultsWhen measuring the effect of ozone on caries progression and recession, the results were inconsistent. The control groups and treatment groups showed a similar rate of progression and recession. The high risk of bias and lack of consistency in outcomes across studies provides no reliable evidence for the efficacy of ozone as an anticariogenic agent.
Evidence Search "ozone treatment of caries"
Comments on
The Evidence
This study consisted of random control trials with similar groups at the start, and each member of that group was treated the same. These were blind studies with adequate compliance from patients. The studies had less than an 80% compliance rate, and the risk for bias in each of the studies appeared high.
Applicability The patients involved in the studies were a good representation of patients in a general-dentistry setting, and the treatment is feasible in such a clinical setting. There was a low risk of harm to the patients, but the patient’s expectations were not met, and the efficacy of the treatment was not established.
Specialty/Discipline (General Dentistry)
Keywords ozone, caries
ID# 2877
Date of submission: 04/01/2015spacer
E-mail chaneya@livemail.uthscsa.edu
Author Andrew Chaney
Co-author(s) e-mail
Faculty mentor/Co-author William Pierpont, DDS
Faculty mentor/Co-author e-mail Pierpont@uthscsa.edu
Basic Science Rationale
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