 |
| Title |
Use of SLS-Free Dentifrices is Beneficial for Patients with Recurrent Aphthous Stomatitis |
| Clinical Question |
In a patient with recurrent aphthous stomatitis, how does the use of sodium lauryl sulfate-free dentifrices compare to the use of SLS-containing dentifrices in terms of incidence of ulcers and pain over a 2-month period? |
| Clinical Bottom Line |
The use of SLS-free dentifrices proves to be beneficial in patients with recurrent aphthous stomatitis in terms of a reduction in both quality of pain and number of ulcers over a 2-month period. |
| Best Evidence |
(you may view more info by clicking on the PubMed ID link) |
| PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
| #1) 22435470 | Shim/2012 | 90 Patients with recurrent aphthous stomatitis. | Randomized Controlled Trial | | Key results | 90 subjects were divided into 3 groups. Group I used an SLS-free dentifrice and SLS-A (SLS-free + 1.5% SLS). Group 2 used SLS-A and SLS-B (commercially available 1.5% SLS-containing dentifrice). Group 3 used SLS-B and SLS-free dentifrices. The groups used one dentifrice for 8 weeks, followed by a 2 week washout period, then used the other dentifrice for 8 weeks. There was no significant difference in the number of aphthous ulcers between the use of SLS-free, SLS-A, and SLS-B. However, the duration of ulcers and mean pain score was significantly lower with the use of the SLS-free dentifrice. | | #2) 8811135 | Herlofson/1996 | 30 Patients with recurrent oral ulcerations. | Randomized Controlled Trial | | Key results | Three different dentifrices, a SLS-containing dentifrice, a cocoamidopropyl betaine (CAPB)-containing dentifrice, and a detergent-free dentifrice were used on 30 subjects with recurrent oral ulcerations. A significantly higher frequency of aphthous ulcers was recorded in the patients that used the SLS-containing dentifrice as compared to the other two. | | #3) 96568647 | Chahine/1997 | Patients with recurrent aphthous ulcers. | Randomized Controlled Trial | | Key results | There was a statistically significant reduction in recurrent aphthous ulcers when using an SLS-free dentifrice for 2 months as compared to using an SLS-containing dentifrice for a 2-month period. | |
| Evidence Search |
"Stomatitis, Aphthous"[Mesh] AND "Sodium Dodecyl Sulfate"[Mesh] |
Comments on
The Evidence |
Validity: The best evidence found (Shim, 2012) was a double-blinded RCT, and this evidence supported the use of SLS-free dentifrices to reduce pain and duration of recurrent aphthous stomatitis (RAS). However, this study showed no significant reduction in the incidence of RAS over the 8-week period. The next study (Herlofson, 1999) was also a double-blinded RCT, and it showed a reduced incidence of RAS with the use of a SLS-free dentifrice but did not evaluate pain levels. The third study (Chanhine, 1997) was not double-blinded; it also showed a reduced incidence and also did not record the quality of pain.
Perspective: The only study that recorded with quality of pain, showed reduced pain. I would believe the other studies would have showed this is they would have recorded it.
|
| Applicability |
Recurrent aphthous stomatitis is a commonly occurring oral disease. The results obtained from this study allow us to recommend the use of SLS-free dentifrices for patients with RAS, in addition to other therapies. |
| Specialty/Discipline |
(Oral Medicine/Pathology/Radiology) (General Dentistry) (Dental Hygiene) |
| Keywords |
Recurrent aphthous stomatitis, sodium lauryl sulfate, SLS, aphthous ulcers, oral ulcerations
|
| ID# |
2700 |
| Date of submission: |
03/21/2014 |
| E-mail |
stapletonm@livemail.uthscsa.edu |
| Author |
Michael Stapleton |
| Co-author(s) |
|
| Co-author(s) e-mail |
|
| Faculty mentor/Co-author |
Robert A. Kaminski, DDS, MS |
| Faculty mentor/Co-author e-mail |
KaminskiR@uthscsa.edu |
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
post a rationale |
| None available | |
|
Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
post a comment |
| None available | |
|
|
