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| Title |
In a Patient Requiring Endodontic Therapy, The use of N2-Sargenti Paste Proves to be Much More Cytotoxic in Comparison with Other Endodontic Sealers |
| Clinical Question |
In a patient requiring endodontic therapy, does the use of N2-Sargenti paste prove more or less cytotoxic, when compared with other endodontic sealers. |
| Clinical Bottom Line |
In a patient requiring endodontic therapy, the use of N2-Sargenti paste proves to be much more cytotoxic in comparison with other endodontic sealers. This is supported by various short and long term experiments each concluding that N2 paste radically reduces cellular metabolism quantified in terms of mitochondrial activity. |
| Best Evidence |
(you may view more info by clicking on the PubMed ID link) |
| PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
| #1) 12470025 | Schwarze/2002 | 30, 10mL samples of cell culture medium. | Laboratory study | | Key results | In comparison with AH Plus, Apexit, Endomethason, and Ketac Endo, N2 thoroughly inhibited cellular metabolism for the duration of each trial when applied directly to the cell cultures. | | #2) 12470017 | Schwarze/2002 | 24 roots of freshly extracted anterior and premolar teeth, in culture media. | Laboratory study | | Key results | The roots of N2-sealed teeth leach endodontic sealer during the setting period; Although most of the cellular changes occurred during the first 5 weeks, alterations to normal growth were exhibited 22 weeks after treatment. N2 sealer does not significantly damage the internal hard tissues of the tooth. | | #3) 11556560 | Tai/2001 | Buccal and gingival fibroblasts. | Laboratory study | | Key results | N2 proved to be significantly cytotoxic when compared with other endodontic sealers. In each of these three studies, 100% of the samples treated with Sargenti paste exhibited degradative cellular changes; compared with Apexit® which displayed a 93.7% mitochondrial activity after treatment, Sargenti paste resulted in a 4.4% mitochondrial activity. | |
| Evidence Search |
(endodontic[All Fields] AND sealer[All Fields]) AND compatibility[All Fields] |
Comments on
The Evidence |
Validity: Each of the three articles were equally valid laboratory studies. Each treated the groups similar at the start, and completed the study to 100%. Each group was treated the same, and being a laboratory study there was no need for patient compliance and followup. There was no evidence of recall bias or competing interests for any of the studies.
Perspective: The successful use of Sargenti paste is largely influenced by technique. It appears that this paste’s improper delivery is the reason for it’s lack of support in the American dental world. It was also for this reason that the studies and reports about this topic were confined to experimental analyses on cell cultures rather than patient populations.
|
| Applicability |
The subjects in these studies were representative of dental patients. The treatment they received is also a feasible treatment to receive in a general dental practice. The use of Sargenti paste is justified for most endodontic situations. There are no contraindication to the use of this substance, however its misuse results in severe consequences; the high risk of tissue inflammation and degeneration are what primarily limits this products use, and makes other endodontic sealers a more reasonable alternative. |
| Specialty/Discipline |
(Endodontics) (General Dentistry) |
| Keywords |
Sargenti, N2 Paste, Endodontics, Endodontic sealer
|
| ID# |
2676 |
| Date of submission: |
03/13/2014 |
| E-mail |
leeed@livemail.uthscsa.edu |
| Author |
Elan Lee |
| Co-author(s) |
|
| Co-author(s) e-mail |
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| Faculty mentor/Co-author |
Ernest Valdez, DDS |
| Faculty mentor/Co-author e-mail |
valdeze@uthscsa.edu |
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
post a rationale |
| None available | |
|
Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
post a comment |
| None available | |
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