ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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Title |
Amelxanox Tablets Is More Effective Than Placebo In Reducing Pain And Ulceration Size In Treatment Of Patients With Recurrent Minor Aphthous Stomatitis |
Clinical Question |
Does Amlexanox treatment in a patient with recurrent minor aphthous stomatitis decrease perceived pain and duration of ulceration compared to placebo? |
Clinical Bottom Line |
For patients with recurrent minor aphthous stomatitis Amelxanox tablets is more effective than placebo in reducing pain and ulceration size. |
Best Evidence |
(you may view more info by clicking on the PubMed ID link) |
PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
#1) 16997114 | Liu/2006 | 212 Patients with minor aphthous stomatitis. Median age 34. | Double blind RCT | Key results | Mean ulcer size in the Amelxanox group was significantly smaller compared to the control group on day 6 (p<.001). The Amlexanox group also presented with a significantly greater efficacy index on day 6, for the reduction of pain (P<.05) and ulcer size (P <.001). | |
Evidence Search |
"Stomatitis, Aphthous/therapy"[Mesh] AND "amlexanox"[Supplementary Concept] |
Comments on
The Evidence |
In Lui’s double blind randomized controlled trial, 212 patients were given Amelxanox for six days. Patients were instructed to self administer Amelxanox tablets 4 times a day, but there is no comments whether patients were compliant with dosage recommendations. Patients had less than 5mm ulcers and were assessed on pain and ulcer size on days 4 and 6. |
Applicability |
Amelxanox treatment was accepted well by patients with minor aphthous stomatitis. This treatment can be used patients ranging from early teens to the elderly. |
Specialty/Discipline |
(General Dentistry) (Dental Hygiene) |
Keywords |
Aphthous Stomatitis
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ID# |
2452 |
Date of submission: |
03/01/2013 |
E-mail |
mcphersonj@livemail.uthscsa.edu |
Author |
James McPherson |
Co-author(s) |
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Co-author(s) e-mail |
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Faculty mentor/Co-author |
John Gildersleeve, DDS |
Faculty mentor/Co-author e-mail |
GILDERSLEEV@uthscsa.edu |
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
post a rationale |
None available | |
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Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
post a comment |
None available | |
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