ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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Title Dentifrices Containing 8% Arginine and Calcium Carbonate Have More Effect on Dentinal Hypersensitivity Relief Than Dentifrices Containing Potassium Nitrate When Used Over 8 Weeks
Clinical Question In patients that have dentinal hypersensitivity, are dentifrices containing 8% arginine and calcium carbonate more effective as a desensitizing agent than dentifrices containing potassium nitrate?
Clinical Bottom Line 2 RCTs proved that dentifrices containing 8% arginine and calcium carbonate showed greater reduction in dentinal hypersensitivity.
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 19831167Docimo/200980 subjectsRCT
Key resultsSubjects that brushed with the dentifrice containing 8% arginine and 1450 ppm fluoride as MFP in a calcium carbonate base showed greater reduction (p < 0.05) in dentin hypersensitivity in response to tactile and air blast stimuli in comparison to subjects who brushed with the desensitizing dentifrice containing 2% potassium ion and 1450 ppm fluoride as NAF in a silica base in a period of 8 weeks.
#2) 22779216Kakar/201288 subjectsRCT
Key resultsSubjects that brushed with the dentifrice containing 8% arginine, calcium carbonate, and 1000 ppm MFP exhibited greater reduction (p < 0.05) in dentin hypersensitivity in response to tactile and air blast stimuli in comparison to subjects who brushed with the 2% potassium ion as potassium nitrate dentifrice in a period of 8 weeks.
Evidence Search "Dentin Sensitivity"[Mesh] AND "potassium nitrate"[Supplementary Concept]) AND "Calcium Carbonate"[Mesh]) AND "Dentifrices"[Mesh]
Comments on
The Evidence
Both articles are Randomized Controlled Trials, with blinding and adequate number of follow-ups (2, 4 and 8 wks). Docimo's study used single-center, parallel group, double-blind, stratified, randomized design. Kakar's study used randomized, single-center, parallel group, double-blind design.
Applicability To patients who are experiencing tooth sensitivity and in need of toothpaste recommendation.
Specialty/Discipline (Public Health) (General Dentistry)
Keywords Dentifrices Dentin hypersensitivity
ID# 2449
Date of submission: 04/08/2013spacer
E-mail hwange3@livemail.uthscsa.edu
Author Eojin Hwang
Co-author(s)
Co-author(s) e-mail
Faculty mentor/Co-author Guy Huynh-Ba, DDS
Faculty mentor/Co-author e-mail HuynhBa@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
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None available
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Comments on the CAT
(FOR PRACTICING DENTISTS' and/or FACULTY COMMENTS ON PUBLISHED CATs)
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