 |
| Title |
Dentifrices Containing 8% Arginine and Calcium Carbonate Have More Effect on Dentinal Hypersensitivity Relief Than Dentifrices Containing Potassium Nitrate When Used Over 8 Weeks |
| Clinical Question |
In patients that have dentinal hypersensitivity, are dentifrices containing 8% arginine and calcium carbonate more effective as a desensitizing agent than dentifrices containing potassium nitrate? |
| Clinical Bottom Line |
2 RCTs proved that dentifrices containing 8% arginine and calcium carbonate showed greater reduction in dentinal hypersensitivity. |
| Best Evidence |
(you may view more info by clicking on the PubMed ID link) |
| PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
| #1) 19831167 | Docimo/2009 | 80 subjects | RCT | | Key results | Subjects that brushed with the dentifrice containing 8% arginine and 1450 ppm fluoride as MFP in a calcium carbonate base showed greater reduction (p < 0.05) in dentin hypersensitivity in response to tactile and air blast stimuli in comparison to subjects who brushed with the desensitizing dentifrice containing 2% potassium ion and 1450 ppm fluoride as NAF in a silica base in a period of 8 weeks. | | #2) 22779216 | Kakar/2012 | 88 subjects | RCT | | Key results | Subjects that brushed with the dentifrice containing 8% arginine, calcium carbonate, and 1000 ppm MFP exhibited greater reduction (p < 0.05) in dentin hypersensitivity in response to tactile and air blast stimuli in comparison to subjects who brushed with the 2% potassium ion as potassium nitrate dentifrice in a period of 8 weeks. | |
| Evidence Search |
"Dentin Sensitivity"[Mesh] AND "potassium nitrate"[Supplementary Concept]) AND "Calcium Carbonate"[Mesh]) AND "Dentifrices"[Mesh] |
Comments on
The Evidence |
Both articles are Randomized Controlled Trials, with blinding and adequate number of follow-ups (2, 4 and 8 wks).
Docimo's study used single-center, parallel group, double-blind, stratified, randomized design.
Kakar's study used randomized, single-center, parallel group, double-blind design.
|
| Applicability |
To patients who are experiencing tooth sensitivity and in need of toothpaste recommendation. |
| Specialty/Discipline |
(Public Health) (General Dentistry) (Dental Hygiene) |
| Keywords |
Dentifrices Dentin hypersensitivity
|
| ID# |
2449 |
| Date of submission: |
04/08/2013 |
| E-mail |
hwange3@livemail.uthscsa.edu |
| Author |
Eojin Hwang |
| Co-author(s) |
|
| Co-author(s) e-mail |
|
| Faculty mentor/Co-author |
Guy Huynh-Ba, DDS |
| Faculty mentor/Co-author e-mail |
HuynhBa@uthscsa.edu |
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
post a rationale |
| None available | |
|
Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
post a comment |
| None available | |
|
|
