ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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Title Elevated Gingival Crevicular Fluid (GCF) Antibody to Aggregatibacter Actinomycetemcomitans in Aggressive Periodontal Patients
Clinical Question In patients with aggressive periodontitis, how effective are gingival crevicular fluid antibodies to Aggregatibacter actinomycetemcomitans in the diagnosis of periodontal disease?
Clinical Bottom Line Elevated Gingival Crevicular Fluid antibodies to A. actinomycetemcomitans and infection in these periodontal patients were found in 87% of the sites analyzed, however, 46% of sites with A. actinomycetemcomitans infection did not have elevated antibody.
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 10890714Ebersole/ 200027 periodontitis patientsCase control study
Key results27 patients, which included 132 sites with elevated antibody and 586 sites with non-elevated antibody, (frequency of elevated antibodies was similar between both patient groups) were used and compared to the subgingival plaque samples (from the same teeth) that were evaluated for the presence of A. actinomycetemcomitans. 87% of the elevated GCF samples were colonized with A. actinomycetemcomitans. Only 46% of the non-elevated GCF samples were colonized by A.a. (p<.001). These results reflect a connection between elevated local antibody and A. actinomycetemcomitans infection.
Evidence Search (("Gingival Crevicular Fluid"[Mesh]) AND "Periodontal Diseases"[Mesh]) AND "Actinobacillus actinomycetemcomitans"[Mesh]
Comments on
The Evidence
Levels of IgG antibody in the GFC samples were collected from each tooth of periodontal patients infected with A. actinomycetemcomitans and were compared with serum. Also, the presence of the disease was determined upon a screening examination. These periodontitis patients include 15 Adult periodontitis patients and 12 Early–onset patients. This research was done with no competing interests.
Applicability Patients expect the clinician to prevent, treat, and eliminate disease. Currently there is no cure for patients with periodontal disease. A GCF antibody screening test, that detects putative periodontal pathogens and the presence of a host inflammatory response, could aid in the ability of a clinician to identify the development of periodontitis before irreversible periodontal destruction has occurred. Analysis of GCF antibody to Aa is affordable, accurate, and could be used as an adjunct in the diagnosis of periodontal patients. The results of these tests can help the clinician understand the disease process of their patients and target their treatments accordingly. Also, it has been suggested that GCF antibody levels to putative periodontal pathogens could be useful in the development of a vaccine.
Specialty/Discipline (General Dentistry) (Periodontics)
Keywords Gingival Crevicular Fluid Antibody, GCF, A. actinomycetemcomitans, periodontitis
ID# 2409
Date of submission: 02/28/2013spacer
E-mail garciamm2@livemail.uthscsa.edu
Author Monique Garcia
Co-author(s)
Co-author(s) e-mail
Faculty mentor/Co-author David P. Cappelli, DMD, MPH, PhD
Faculty mentor/Co-author e-mail CAPPELLI@uthscsa.edu
Basic Science Rationale
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