ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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Title Stannous Containing Fluoride Dentifrice is Effective in Reducing Oral Malodor
Clinical Question In an adult individual with bad oral odor, can stannous containing fluoride dentifrice reduce oral malodor when compared to sodium containing fluoride dentifrice?
Clinical Bottom Line The use of dentifrice containing stannous fluoride effectively reduces the bad odor associated with oral cavity.
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 21280424Feng/ 2010Patients exhibiting oral malodorMeta-Analysis
Key resultsThere was statistically significant greater breath benefits in stannous containing sodium fluoride dentifrice when compared to the negative control sodium fluoride dentifrice (Crest Cavity Protection), with a P value of < 0.047 at all three time points which includes, 3-4 hours, after 24 hours and 27-28 hours post baseline.
#2) 18186171Farrell/2007Patients exhibiting oral malodor Randomized Controlled Trial
Key resultsUse of stannous fluoride dentifrice in the two double-blinded studies resulted in significant and immediate reduction of oral malodor with VSC (P < 0.03) and the overnight 9-point hedonic scores (P < 0.02) relative to negative control of sodium fluoride after a day of product use.
#3) 20718217Chen/ 2010Patients exhibiting oral malodorRandomized Controlled Trial
Key resultsIt was found that adjusted mean volatile sulfur compound (VSC) levels were significantly lower in the group treated with stannous fluoride dentifrice than the sodium fluoride dentifrice group, with P values < 0.01 and < 0.001 at 24 and 28 hours post-baseline time points respectively.
Evidence Search (("Dentifrices"[Mesh]) AND "Halitosis"[Mesh]) AND "Tin Compounds"[Mesh]
Comments on
The Evidence
Feng reported his article as meta analysis of four randomized and two crossover controlled clinical trials. Chen and Farrell reported their articles as randomized studies. For each article the groups were similar at the start and adequate follow up was done. Recall bias was unlikely. The compliance shown was also adequate. Chen and Farrell’s articles show that 0.454 % SnF2 dentifrice is more effective in oral malodor protection. Similar results were also found in Feng’s article.
Applicability The patients in these reviews are very representative of everyday patients that exhibit oral malodor. The treatment can be incorporated in any dental clinic or home care. The potential benefits of both immediate and long-term breath malodor reduction were seen in both studies.
Specialty/Discipline (Public Health) (General Dentistry)
Keywords Dentifrices, halitosis, tin compounds, stannous fluoride.
ID# 2397
Date of submission: 03/07/2013spacer
E-mail zafer@livemail.uthscsa.edu
Author Naila Zafer
Co-author(s)
Co-author(s) e-mail
Faculty mentor/Co-author Juanita Lozano-Pineda, DDS, MPH
Faculty mentor/Co-author e-mail pinedaj@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
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Comments on the CAT
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