ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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Title Unclear If Administration of Amifostine Reduces the Symptoms of Xerostomia Following Treatment of Head and Neck Cancer
Clinical Question In a patient experiencing xerostomia as a result of head and neck cancer treatment, does a radio protective drug such as amifostine, as compared to no treatment, effectively reduce the signs and symptoms of xerostomia perceived by the patient?
Clinical Bottom Line Based on the available evidence, it is still unclear whether the use of amifostine during head and neck cancer treatment is effective in reducing xerostomia symptoms perceived by the patient. The available evidence seems inconclusive and more research is required.
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 19634161Haddad/200958 patients undergoing chemotherapy to the head and neckRCT
Key resultsTwo groups of treatment, one with amifostine administration, the other without. No reported difference of salivary output between the two groups.
Evidence Search ("Amifostine"[Mesh]) AND "Xerostomia"[Mesh]
Comments on
The Evidence
This was a randomized controlled trial in which the patients all had stage III or IV squamous cell carcinoma in the head and neck region. A double-blind was not indicated in the article. The trial was intended to have a sample size of 80, however it was discontinued before this goal was reached, so an 80% completion rate was not achieved. Two groups were divided for the trial, one receiving amifostine and the other without. Of the samples completed, adequate follow-up was achieved and patient compliance was adequate. There appeared to be no recall bias and there were no apparent competing interests.
Applicability Any practitioner advising a patient anticipating treatment for head and neck cancer can use this information to advise on potential options during their treatment.
Specialty/Discipline (Oral Medicine/Pathology/Radiology) (General Dentistry) (Oral Surgery)
Keywords amifostine, saliva, head and neck cancer treatment
ID# 2382
Date of submission: 03/07/2013spacer
E-mail rathke@livemail.uthscsa.edu
Author Bryan Rathke
Co-author(s)
Co-author(s) e-mail
Faculty mentor/Co-author David Cox, DDS
Faculty mentor/Co-author e-mail CoxD@uthscsa.edu
Basic Science Rationale
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