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Title Fluoride Is More Effective Than Xylitol At Preventing Caries
Clinical Question In patients susceptible to dental caries, is fluoride more effective than xylitol at preventing caries?
Clinical Bottom Line Fluoride is better than xylitol at preventing caries, but fluoride with xylitol is better than fluoride alone.
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 21712620Rochel/201120 bovine samplesIn Vitro Study of Bovine Teeth
Key resultsFluoride performed better at preventing enamel erosion than xylitol, but fluoride plus xylitol performed better than either component alone (P=.008).
#2) 21940519Takahashi/20117 patientsRandomized Control Trials
Key resultsFluoride decreased acid production in vivo by inhibiting bacterial enolase. Xylitol did not affect acid production. P=.017
#3) 18341562Stecksen-Blicks/2008160 high caries risk 10-12 year old patientsRandomized Controlled Trials
Key resultsUsing lozenges with xylitol or both xylitol and fluoride did not affect the development of caries in high caries risk children. Also, there was no significant difference between the two groups (p>.05).
Evidence Search ("Fluorides"[Mesh]) AND "Xylitol"[Mesh]
Comments on
The Evidence
The studies listed seemed to have differing results in terms of effectiveness of fluoride versus xylitol. While it was shown that fluoride is better than xylitol at decreasing acid production, neither alone nor together did fluoride and xylitol reduce caries when given in a lozenge.
Applicability These studies are representative of the patients one would see in a general practice. One study focused on bovine enamel in vitro but was treated with artificial saliva and should still be applicable.
Specialty/Discipline (Public Health)
Keywords fluoride xylitol
ID# 2253
Date of submission: 04/25/2012spacer
E-mail wallach@livemail.uthscsa.edu
Author David Wallach
Co-author(s) e-mail
Faculty mentor/Co-author Suman Challa, BDS, MS
Faculty mentor/Co-author e-mail Challas@uthscsa.edu
Basic Science Rationale
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