ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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Title Replacement Therapy in Aphthous Stomatitis Patients
Clinical Question In patients with nutritional deficiency suffering from aphthous stomatitis, does replacement therapy decrease the recurrence when compared to untreated patients?
Clinical Bottom Line Ascorbate supplementation and Vitamin B12 supplementation are effective treatment options in patients suffering from recurrent aphthous stomatitis. More research is needed.
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 19124628Volkov/200958 patients with RASRCT
Key resultsA sublingual dose of 1000 mcg vitamin B12 daily lessened the duration, number, and amount of pain of aphthous ulcers.
#2) 20003102Yasui/200916 patients with RASCase Series
Key resultsOral ascorbate treatment, with dosage assigned using 2000 mg/m(2)/day, reduced the recurrence and pain of aphthous ulcers.
Evidence Search "Stomatitis, Aphthous/therapy"[Mesh]
Comments on
The Evidence
A larger sample size and a control group would benefit the validity of both studies. Longer follow up with the supplemental treatment would also be beneficial.
Applicability This information could be used in clinic when counseling patients with recurrent aphthous stomatitis.
Specialty/Discipline (Oral Medicine/Pathology/Radiology) (General Dentistry) (Pediatric Dentistry) (Periodontics)
Keywords Recurrent Aphthous Stomatitis Therapy
ID# 2228
Date of submission: 04/19/2012spacer
E-mail padgett@livemail.uthscsa.edu
Author Chelsea Padgett
Co-author(s)
Co-author(s) e-mail
Faculty mentor/Co-author Georgiana S. Gross, MPH
Faculty mentor/Co-author e-mail GROSSG@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
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None available
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Comments on the CAT
(FOR PRACTICING DENTISTS' and/or FACULTY COMMENTS ON PUBLISHED CATs)
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