ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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Title Platelet-Rich Plasma Increases The Rate Of Initial Bone Formation In Sinus Grafts
Clinical Question In a healthy patient who needs a lateral window sinus augmentation for future implant placement, will the addition of Platelet-Rich Plasma (PRP) to the sinus graft increase the rate of bone formation?
Clinical Bottom Line The rate of early bone formation in sinus augmentations is increased when platelet-rich plasma is added to the sinus graft at the time of surgery.
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 21091351Bae/2011191 healthy patients, 352 sinus liftsMeta-Analysis
Key resultsMeta-analysis of 5 randomized controlled trials using the random-effects model showed that bone formation significantly increased in the sinus grafts with PRP (SMD: 1.30, 95% CI: 0.21 to 2.39). There was significant heterogeneity between the studies (I2=76.2%). One outlier study was excluded from the subgroup meta-analysis.
Evidence Search "Bone Transplantation"[Mesh] OR “Dental Implantation"[Mesh] AND "platelet-rich plasma”
Comments on
The Evidence
The overall power of the evidence provided is weakened by the significant heterogeneity of the studies and the small number of RCTs included in the meta-analysis. The 5 studies included in the random-effects meta-analysis showed a consistent trend of increased early bone formation when PRP was added to the sinus graft, regardless of the type of bone graft used in the sinus augmentation. Further RCT’s are required to increase the power of the results.
Applicability This meta-analysis included studies that calculated the effects of PRP on bone formation in sinus grafts between 3 and 6 months. The results from this meta-analysis are mainly applicable to sinus augmentations using PRP with autogenous bone grafts from the iliac crest or mandibular ramus. The data supporting use of PRP with FDBA or inorganic bovine bone grafts was limited to two studies. Additional RCT’s are needed to confirm the use of PRP with xenografts and allografts.
Specialty/Discipline (Oral Surgery) (Periodontics)
Keywords Platelet-rich Plasma, PRP, Sinus, Sinus Lift, Sinus Augmentation, Lateral Window Sinus Augmentation
ID# 2118
Date of submission: 12/19/2011spacer
E-mail caldwellg@uthscsa.edu
Author Gregory R. Caldwell, DDS, MS
Co-author(s)
Co-author(s) e-mail
Faculty mentor/Co-author Richard S. Finlayson, DDS
Faculty mentor/Co-author e-mail
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
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Comments on the CAT
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