ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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Title |
Limited Evidence Suggests An Association Of Adverse Pregnancy Outcomes With Mothers Who Have Periodontal Disease |
Clinical Question |
What is the likelihood of pre-term birth with mothers who have periodontal disease? |
Clinical Bottom Line |
Mothers with periodontal disease are shown to have an increased risk ratio for pre-term delivery and low birth weight babies. However, caution must be used when reporting this association because it is based on prospective cohort studies, which cannot verify cause and effect of completely rule out confounding effects. (See Comments on the CAT below) |
Best Evidence |
(you may view more info by clicking on the PubMed ID link) |
PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
#1) 21707694 | Chambrone/2011 | 12,171 Pregnant Mothers | Meta-Analysis of Prospective Cohort Studies | Key results | The risk ratio of pre-term birth for pregnant mothers with periodontal disease was 1.70 with a 95% confidence interval of 1.03-2.81. The risk ratio of low birth weight babies was 2.11 with a 95% confidence interval of 1.05-4.23. The risk ratio of PD/LBW was 3.57 with a 95% confidence interval of 1.87-6.84. | |
Evidence Search |
systematic[sb] AND (("periodontitis"[MeSH Terms] OR "periodontitis"[All Fields]) AND ("premature birth"[MeSH Terms] OR ("premature"[All Fields] AND "birth"[All Fields]) OR "premature birth"[All Fields] OR ("preterm"[All Fields] AND "birth"[All Fields]) OR "preterm birth"[All Fields])) |
Comments on
The Evidence |
A meta-analysis of 11 prospective cohort studies supports this evidence. 12,173 patients were included in these studies. A comprehensive, detailed search for relevant trials was performed. These studies were assessed individually for validity. Further research is needed to verify the validity of this association because these studies are all progressive cohort studies, which cannot verify cause and effect as well as completely control for confounding factors. |
Applicability |
Applicable to pregnant mothers with a history of periodontitis. The research subjects were from several different countries. |
Specialty/Discipline |
(Periodontics) (Dental Hygiene) |
Keywords |
"periodontitis" and "pregnancy"
|
ID# |
2113 |
Date of submission: |
09/21/2011 |
E-mail |
gallowayp@uthscsa.edu |
Author |
Patrick Galloway |
Co-author(s) |
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Co-author(s) e-mail |
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Faculty mentor/Co-author |
Richard Finlayson, DDS |
Faculty mentor/Co-author e-mail |
finlaysonr@uthscsa.edu |
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
post a rationale |
None available | |
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Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
post a comment |
by Kayleigh Eaves (San Antonio, TX) on 07/10/2012 The second part of this Cochrane Analysis was recently published and continues to support this CAT. PMID 21736600
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