Title |
Addition of Tricolsan in a Dentifrice Provides More Effective Control of Plaque and Periodontal Health Than Conventional Fluoride Dentifrice |
Clinical Question |
In an adult patient with generalized gingivitis, will triclosan based dentifrices reduce the plaque of a patient better than fluoride based dentifrices? |
Clinical Bottom Line |
The addition of a broad spectrum antibacterial agent, triclosan, provides a more effective level of plaque control and periodontal health than conventional fluoride dentifrice. |
Best Evidence |
|
PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
15560802 | Davies/2004 | Adults (18 years old or more) with plaque and gingivitis | Meta-Analysis & Systemic Review of Randomized Controlled Trials | Key results | The meta-analysis for both the Quigley-Hein plaque index (QHPI) and plaque severity index showed that the triclosan/copolymer dentifrice is effective in reducing plaque compared with a fluoride dentifrice, with weighted mean difference (WMD) of -0.48 (95% confidence interval (CI) (random effects): -0.64 to -0.32) for the QHPI (0-5 scale) and a WMD of -0.15 (95% CI (random effects): -0.20 to -0.09) for the plaque severity index. When compared with a fluoride dentifrice, the triclosan/copolymer dentifrice significantly reduced gingivitis with WMDs -0.26 (95% CI: -0.34 to -0.18) and -0.12 (95% CI: -0.17 to -0.08) for the Loe and Silness index and gingivitis severity index. The plaque and gingivitis severity indices demonstrated that the triclosan reduced the proportion of surfaces with heavy plaque by 15% and those with gingival bleeding by 12%. | 17138709 | Gunsolley/2006 | Normal adults | Meta-Analysis & Systemic Review of Randomized Controlled Trials | Key results | Dentifrices containing 0.30% triclosan, 2% Gantrez copolymer exhibited statistically significant results that support its effect for anti-plaque on 14/18 arms (representing 17 studies) with a mean standard difference of 0.823 (P < .0001) and mean standard difference of 0.858 for anti-gingivitis. | |
Evidence Search |
("Triclosan"[Mesh] AND "Fluorides"[Mesh]) AND "Dentifrices"[Mesh] AND Meta-Analysis[ptyp] |
Comments on
The Evidence |
The article reported a systematic review of triclosan dentifrice use for plaque and gingivitis, including 16 trials, comparing fluoride dentifrices. These trials were selected based on the criteria of being randomized, of at least 6 months in duration, conducted on adults with plaque and gingivitis, comparing a dentifrice with containing 0.3% triclosan, 2% copolymer, and 0.243 % sodium fluoride in a silica base with a fluoride dentifrice for plaque or gingivitis. The authors conducted a comprehensive and detailed search using the Cochrane Controlled Trials Register, MEDLINE (1986 to March 2003) and EMBASE (1986 to March 2003). a meta-analysis was done. Since the authors are employees at Colgate, a manufacturer of oral hygiene products, potential bias may be of concern. Article may be biased toward the promotion of Colgate products. |
Applicability |
The results of this study can be applied to patients who experience issues with plaque control and gingivitis. Patients benefit from improved gingival health and reduction in gingival bleeding. |
Specialty |
(General Dentistry) (Periodontics) (Dental Hygiene) |
Keywords |
Gingivitis, plaque, triclosan, toothpaste, fluoride
|
ID# |
2271 |
Date of submission |
04/19/2012 |
E-mail |
nguyenhq@livemail.uthscsa.edu |
Author |
Hieu Nguyen |
Co-author(s) |
|
Co-author(s) e-mail |
|
Faculty mentor |
Yong-Hee Patricia Chun, DDS, MS, PhD |
Faculty mentor e-mail |
chuny@uthscsa.edu |
|
|
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
None available | |
|
Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
None available | |