Title |
Replacement Therapy in Aphthous Stomatitis Patients |
Clinical Question |
In patients with nutritional deficiency suffering from aphthous stomatitis, does replacement therapy decrease the recurrence when compared to untreated patients? |
Clinical Bottom Line |
Ascorbate supplementation and Vitamin B12 supplementation are effective treatment options in patients suffering from recurrent aphthous stomatitis. More research is needed. |
Best Evidence |
|
PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
19124628 | Volkov/2009 | 58 patients with RAS | RCT | Key results | A sublingual dose of 1000 mcg vitamin B12 daily lessened the duration, number, and amount of pain of aphthous ulcers. | 20003102 | Yasui/2009 | 16 patients with RAS | Case Series | Key results | Oral ascorbate treatment, with dosage assigned using 2000 mg/m(2)/day, reduced the recurrence and pain of aphthous ulcers. | |
Evidence Search |
"Stomatitis, Aphthous/therapy"[Mesh] |
Comments on
The Evidence |
A larger sample size and a control group would benefit the validity of both studies. Longer follow up with the supplemental treatment would also be beneficial. |
Applicability |
This information could be used in clinic when counseling patients with recurrent aphthous stomatitis. |
Specialty |
(Oral Medicine/Pathology/Radiology) (General Dentistry) (Pediatric Dentistry) (Periodontics) |
Keywords |
Recurrent Aphthous Stomatitis Therapy
|
ID# |
2228 |
Date of submission |
04/19/2012 |
E-mail |
padgett@livemail.uthscsa.edu |
Author |
Chelsea Padgett |
Co-author(s) |
|
Co-author(s) e-mail |
|
Faculty mentor |
Georgiana S. Gross, MPH |
Faculty mentor e-mail |
GROSSG@uthscsa.edu |
|
|
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
None available | |
|
Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
None available | |