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Title Doubtful Link Between Hepatitis C Infection & Presence Of Hyposalivation
Clinical Question Is there a relationship between development of xerostomia/hyposalivation & the presence of salivary hepatitis C viral RNA?
Clinical Bottom Line There does not seem to be a link between the presence of Hepatitis C viral RNA in saliva as a cause of hyposalivation or xerostomia in patients with chronic hepatitis C infection, but evidence specific to clinical question is limited. (See Comments on the CAT below)
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 20451844Soraya de Matos/2010 Patients with confirmed diagnosis of chronic hepatitis C infectionCase control
Key resultsWhile there appears to be an increase in incidence of hyposalivation/xerostomia in patients with chronic Hepatitis C infection, there does not appear to be a correlation between hyposalivation and detection of HCV RNA in saliva.
Evidence Search ("Hepatitis C"[Mesh]) AND "Xerostomia"[Mesh] ...view in PubMed
Comments on
The Evidence
A PCR test was used as the gold standard to detect the presence of HCV RNA in patients. Saliva during non-stimulated salivary flow was collected over a 3-minute period in these patients. This same standard was applied to all patients in the sample pool.
Applicability This type of study could be applied in practice. These tests are available to clinicians. Determination of the likelihood that patients with Hepatitis C infection will develop hyposalivation may allow a clinician to more appropriately treat these patients and educate them with respect to potential development of hyposalivation and subsequent disease.
Specialty/Discipline (Oral Medicine/Pathology/Radiology) (General Dentistry) (Basic Science)
Keywords Hepatitis C, hyposalivation, xerostomia
ID# 750
Date of submission: 03/29/2011spacer
E-mail tunnell@livemail.uthscsa.edu
Author John Tunnell
Co-author(s) e-mail
Faculty mentor/Co-author Geza Terezhalmy, DDS
Faculty mentor/Co-author e-mail TEREZHALMY@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
post a rationale
None available
Comments and Evidence-Based Updates on the CAT
post a comment
by Tyler Martini, Michael Young, Susie DeKoch (San Antonio, Texas) on 01/06/2014
A PubMed search on xerostomia/hyposalivation and hepatitis C on January 2014 found limited related evidence. There was a more recent publication, PubMed ID 22489018 Maryam, 2012. This case-control study further supports the conclusions of this CAT.

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