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Title Ibuprofen Does Not inhibit orthodontic tooth movement Shown In Animal Studies
Clinical Question In a healthy orthodontic patient, does ibuprofen taken for pain management inhibit orthodontic tooth movement more than acetaminophen?
Clinical Bottom Line Ibuprofen does inhibit orthodontic tooth movement. This should be considered when pain medication is necessary for orthodontic patients. (See Comments on the CAT below)
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 19121496Bartzel/200949 articles were included, mainly animal studiesSystematic Review of animal studies
Key resultsThe authors found that ibuprofen in unknown doses inhibited tooth movement in rats, whereas when administered in low doses (10 mg/kg/day) in rabbits, no effect was seen. Acetaminophen showed no inhibitory effect in the studies reviewed and is recommended by the authors as the drug of choice for pain management with orthodontic treatment.
Evidence Search PubMed search using "Orthodontics"[Mesh] AND "Analgesics"[Mesh]
Comments on
The Evidence
The articles reviewed consist almost entirely of animal studies. The review mainly summarizes the effects of each drug individually because different methods used in each study varied greatly and precluded direct comparison of the effects of two medications.
Applicability This applies to orthodontists and their patients, and also to general dental practitioners who treat orthodontic patients. The low level of evidence (mostly animal studies) should be acknowledged.
Specialty/Discipline (Orthodontics)
Keywords Orthodontics; analgesics; tooth movement; pain; ibuprofen; acetaminophen
ID# 623
Date of submission: 03/30/2010spacer
E-mail FrancisJ@livemail.uthscsa.edu
Author J. Christian Francis
Co-author(s) e-mail
Faculty mentor/Co-author Dubravko Pavlin, DMD, PhD
Faculty mentor/Co-author e-mail PAVLIN@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
post a rationale
None available
Comments and Evidence-Based Updates on the CAT
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by Dana Matlock (San Antonio, TX) on 04/20/2012
On April 20th, 2012, a PubMed search was performed on this topic. After reviewing the publications on PubMed, it was determined that the publication used in this CAT is the best available evidence. This publication is found to be recent, and it has the best evidence for this topic as the publication was based on a systemic review.

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