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Title Use Of Emdogain In The Treatment Of Gingival Recession
Clinical Question In an adult patient with gingival recession, does using Emdogain, as opposed to not using Emdogain, enhance the outcome of periodontal surgery?
Clinical Bottom Line The use of Emdogain can enhance the benefits of surgery in a patient with gingival recession. (See Comments on the CAT below)
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 19370675 Chambrone/200924 randomized controlled trialsMeta-Analysis
Key resultsBased on the 24 randomized controlled trials included in this meta-analysis, the authors concluded that the use of enamel matrix protein (Emdogain) resulted in a greater increase of keratinized tissue when compared to a coronally advanced flap alone.
#2) 18724847Cairo/2008530 patients from 25 RCTs Systematic Review
Key resultsThe use of enamel matrix derivative (Emdogain) in conjunction with a coronally advanced flap yields a greater probability of obtaining complete root coverage.
Evidence Search (enamel matrix proteins;[Substance Name] AND; Gingival Recession;[Mesh])
Comments on
The Evidence
The evidence consists of a meta-analysis and a systematic review, the 2 highest levels of evidence available.
Applicability These results are applicable to adult patients with mild gingival recession. Cairo et. al limited their study to Miller Class I and II single gingival recessions and their results may not be applicable to patients with more severe recession.
Specialty/Discipline (Periodontics)
Keywords Gingival recession, emdogain, enamel matrix derivative, enamel matrix protein, coronally advanced flap, periodontal regeneration
ID# 497
Date of submission: 01/07/2010spacer
Author Ashley Jackson
Co-author(s) Elizabeth Wallmann
Co-author(s) e-mail elizabeth.wallmann@gmail.com
Faculty mentor/Co-author Bjorn Steffensen, DDS
Faculty mentor/Co-author e-mail SteffensenB@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
post a rationale
None available
Comments and Evidence-Based Updates on the CAT
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by Chungmi Jo (San Antonio, TX) on 04/13/2012
After searching on PubMed on April 2012, I have found a more recent publication that is applicable to this CAT: PubMed ID 21491012. This randomized controlled clinical trial was conducted with 56 Millar Class I and Class II gingival recession. According to this study, when connective tissue graft alone (CTG) was compared to combination of CTG and EMD, results were statistically insignificant.

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