ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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| Title |
The Anticariogenic Benefit of Topical Ozone as a Management Technique for Active Carious Lesions Has Not Been Demonstrated |
| Clinical Question |
In patients with non-cavitated carious lesions, does the application of ozone to the surface of the carious lesions lead to a regression of the caries when compared to a placebo treatment? |
| Clinical Bottom Line |
The clinical use of ozone as an anticariogenic agent in non-cavitated lesions is unreliable based on current research. The lack of efficacy is supported by a systematic review of three randomized control trials. The use of ozone showed similar results to the placebo treatment. |
| Best Evidence |
(you may view more info by clicking on the PubMed ID link) |
| PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
| #1) 15266519 | Rickard/2004 | 3 studies with 137 patients | Systematic review of non-randomized trials | | Key results | When measuring the effect of ozone on caries progression and recession, the results were inconsistent. The control groups and treatment groups showed a similar rate of progression and recession. The high risk of bias and lack of consistency in outcomes across studies provides no reliable evidence for the efficacy of ozone as an anticariogenic agent. | |
| Evidence Search |
"ozone treatment of caries" |
Comments on
The Evidence |
This study consisted of random control trials with similar groups at the start, and each member of that group was treated the same. These were blind studies with adequate compliance from patients. The studies had less than an 80% compliance rate, and the risk for bias in each of the studies appeared high. |
| Applicability |
The patients involved in the studies were a good representation of patients in a general-dentistry setting, and the treatment is feasible in such a clinical setting. There was a low risk of harm to the patients, but the patient’s expectations were not met, and the efficacy of the treatment was not established. |
| Specialty/Discipline |
(General Dentistry) |
| Keywords |
ozone, caries
|
| ID# |
2877 |
| Date of submission: |
04/01/2015 |
| E-mail |
chaneya@livemail.uthscsa.edu |
| Author |
Andrew Chaney |
| Co-author(s) |
|
| Co-author(s) e-mail |
|
| Faculty mentor/Co-author |
William Pierpont, DDS |
| Faculty mentor/Co-author e-mail |
Pierpont@uthscsa.edu |
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
post a rationale |
| None available | |
|
Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
post a comment |
| None available | |
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