ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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Title Silver Nanoparticle (AgNP)-Containing Resin Bonding Systems Significantly Reduced the Viability of Caries-Related Bacteria and Plaque Biofilms
Clinical Question In patients with class 1, class 2, or class 5 composite restorations, is the incidence of secondary caries lower when using silver nanoparticle-incorporated resin bonding systems compared to conventional resin bonding systems?
Clinical Bottom Line Studies performed in vitro demonstrated the inhibition of caries-related Streptococcus mutans and plaque-forming oral bacteria when AgNPs were incorporated into resin bonding systems. This is based on studies showing a reduction in metabolic activity, number of colony forming units (CFUs), and lactic acid production in the AgNP adhesives compared to the controls.
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 23428077Li/2013Streptococcus mutans biofilm on primer/adhesive disks, N=6Laboratory study
Key resultsUse of primers and bonding agents containing nanopartices of silver significantly reduced the biofim growth, number of CFUs, lactic acid production, and metabolic activity of S. mutans compared to the control. AgNP-containing experimental groups demonstrated inhibition of both surface bacteria as well as bacteria located away from the surface in the medium, with the number of CFUs 1/3 of that of the control (p < 0.05).
#2) 23529901Zhang/2013Human saliva-derived multi-species biofilm on adhesive disks, N=6Laboratory study
Key resultsUse of silver nanoparticle-containing bonding agents greatly reduced the number of CFUs, metabolic activity, and lactic acid production of caries-related plaque biofilms to nearly 1/3 of that of the control (p <0.05).
Evidence Search nano-silver[All Fields] AND ("adhesives"[MeSH Terms] OR "adhesives"[All Fields] OR "adhesive"[All Fields])
Comments on
The Evidence
Validity: Clinical trials have not yet been established to date for the use of AgNP-incorporated bonding systems. However, the relevance of these studies to the clinical question does indicate their validity. Perspective: Based on these studies, the use of AgNPs incorporated into a resin bonding system could potentially provide a means to reduce the incidence of secondary caries in composite restorations. However, further study would be required to evaluate the long-term effects of AgNPs in bonding systems and their clinical effects in a patient’s oral environment.
Applicability With the incidence of secondary caries being the leading cause of composite restoration failure it becomes crucial to find solutions that do not compromise the overall health of the patient and the effectiveness of the restoration. Evidence presented by these studies indicate that AgNP-incorporated bonding systems are effective in inhibiting caries-causing bacteria while also not compromising the microtensile strength of the restoration and biocompatibility with the patient.
Specialty/Discipline (General Dentistry) (Restorative Dentistry)
Keywords Silver Nanoparticles, Antimicrobial, Adhesive, dentin bonding agent
ID# 2841
Date of submission: 03/27/2015spacer
E-mail oei@livemail.uthscsa.edu
Author James D. Oei
Co-author(s)
Co-author(s) e-mail
Faculty mentor/Co-author Kyumin Whang, PhD
Faculty mentor/Co-author e-mail whang@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
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Comments on the CAT
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