ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM
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| Title |
Thymoquinone Has Anti-Tumor Effects on Squamous Cell Carcinoma in Mice |
| Clinical Question |
Does thymoquinone have anti-tumor effects in patients with oral squamous cell carcinoma? |
| Clinical Bottom Line |
Thymoquinone has not been shown to be effective against oral squamous cell carcinoma in humans. The drug, however, has been shown to have anti-tumor effects against squamous cell carcinoma in mouse models. |
| Best Evidence |
(you may view more info by clicking on the PubMed ID link) |
| PubMed ID |
Author / Year |
Patient Group |
Study type
(level of evidence) |
| #1) 17080016 | Ivankovic/2006 | In vivo: cell lines; in vitro: mouse tumor models | Laboratory study | | Key results | Thymoquinone was shown to have good antitumor activity on both squamous cell carcinoma (SCC VII) and fibrosarcoma (FsaR) cells in mice. The therapeutic effect achieved was 49% against SCC VII and 33% against FsaR. | |
| Evidence Search |
Squamous Cell Carcinoma AND Thymoquinone |
Comments on
The Evidence |
This study is valid because the control and test groups were the same at the start of experiment and they were treated the same. There does not seem to be any conflict of interest by the authors. The authors compared the tumor response to thymoquinone and thymohydroquinone of the test groups to the control group that received no treatment. |
| Applicability |
The significant anti-tumor effects demonstrated in these pre-clinical mouse xenograft models provide rationale to translate this finding to a clinical application for oral cancer patients. Importantly, phase I clinical studies of thymoquinone demonstrated that it is non-toxic to humans. Therefore, thymoquinone may provide a new therapy for oral cancer patients. |
| Specialty/Discipline |
(Oral Medicine/Pathology/Radiology) (Oral Surgery) (Basic Science) |
| Keywords |
Carcinoma, Squamous Cell, Tumor, Mice, Drug Therapy, Thymoquinone
|
| ID# |
2784 |
| Date of submission: |
12/05/2014 |
| E-mail |
Leed7@uthscsa.edu |
| Author |
Debbie R. Lee, DDS |
| Co-author(s) |
|
| Co-author(s) e-mail |
|
| Faculty mentor/Co-author |
Cara Gonzales, PhD, DDS |
| Faculty mentor/Co-author e-mail |
gonzalesc5@uthscsa.edu |
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?) |
post a rationale |
| None available | |
|
Comments and Evidence-Based Updates on the CAT
(FOR PRACTICING DENTISTS', FACULTY, RESIDENTS and/or STUDENTS COMMENTS ON PUBLISHED CATs) |
post a comment |
| None available | |
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