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Title Human Bone is Preferable to Bovine Bone in Socket Preservation Grafting
Clinical Question In an adult patient who is receiving a bone graft for socket preservation, will the use of human bone promote better clinical healing in comparison to bovine bone over 3 months?
Clinical Bottom Line Both human and bovine grafting materials are effective in socket preservation following extraction’s, however human bone allows for quicker growth of vital bone within 3 months, which makes it a more favorable material for socket preservation.
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 17243327Froum/2006 13 patients total; 11 patients were chosen for samplesRandomized Controlled Trials
Key resultsSignificantly more bone was formed in the sites with mineralized human cancellous bone allograft (MCBA). Histologically, both grafts were surrounded by new bone, osteoid, and osteoblasts, but a higher percentage of vital native bone was seen around the human allograft particles in comparison to the bovine graft.
#2) 19885400Lee/200920 patientsComparative clinical study
Key resultsThe deproteinized bovine bone material (DBBM) induced more new bone deposition around the graft particles than the allograft in this study. However, the DBBM xenograft retained more of the residual graft particles over the study period. The human allograft material proved to be more effective for intact bony defects and fresh socket extraction sites since it was more rapidly resorbed, allowing more vital bone to form faster.
Evidence Search (("Transplantation, Homologous"[Mesh]) AND "Alveolar Ridge Augmentation"[Mesh]) AND "Cattle"[Mesh]
Comments on
The Evidence
The evidence on bovine bone versus human bone for socket preservation shows that both materials can be effective, however, the human bone is the preferred material. The bovine graft is more slowly resorbed and there is a higher presence of residual particles after a 3 month period compared to vital bone. The human allograft particles will resorb faster and can induce a higher percentage of native vital bone at a faster rate, which is why it is considered the best material for immediate socket preservation.
Applicability This evidence is applicable to patients receiving bone grafting for socket preservation or ridge augmentation.
Specialty/Discipline (General Dentistry) (Oral Surgery) (Periodontics)
Keywords Aveolar bone graft, Ridge preservation, allograft, xenograft
ID# 2189
Date of submission: 03/30/2012spacer
E-mail larivey@livemail.uthscsa.edu
Author Danielle Larivey
Co-author(s) e-mail
Faculty mentor/Co-author Richard Finlayson, DDS
Faculty mentor/Co-author e-mail finlaysonr@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
post a rationale
None available
Comments and Evidence-Based Updates on the CAT
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by Valerie Cano and Pender Morrow (San Antonio, Texas) on 11/30/2017
A PubMed search on using human bone vs. bovine bone for socket preservation grafting was performed in November 2017. There was a more recent article found that supports this CAT: Sadeghi/2016 (PMID: 27076830). This article was primary research - a randomized study of deproteinized bovine bone mineral and demineralized freeze-dried bone allograft. The results were similar to the conclusion of the CAT; both materials had a positive effect on alveolar ridge preservation. However, more new bone formation and less residual graft particles were observed with the freeze-dried bone allograft when compared to deproteinized bovine bone mineral.

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