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Title Limited Evidence Suggests An Association Of Adverse Pregnancy Outcomes With Mothers Who Have Periodontal Disease
Clinical Question What is the likelihood of pre-term birth with mothers who have periodontal disease?
Clinical Bottom Line Mothers with periodontal disease are shown to have an increased risk ratio for pre-term delivery and low birth weight babies. However, caution must be used when reporting this association because it is based on prospective cohort studies, which cannot verify cause and effect of completely rule out confounding effects. (See Comments on the CAT below)
Best Evidence (you may view more info by clicking on the PubMed ID link)
PubMed ID Author / Year Patient Group Study type
(level of evidence)
#1) 21707694Chambrone/201112,171 Pregnant MothersMeta-Analysis of Prospective Cohort Studies
Key resultsThe risk ratio of pre-term birth for pregnant mothers with periodontal disease was 1.70 with a 95% confidence interval of 1.03-2.81. The risk ratio of low birth weight babies was 2.11 with a 95% confidence interval of 1.05-4.23. The risk ratio of PD/LBW was 3.57 with a 95% confidence interval of 1.87-6.84.
Evidence Search systematic[sb] AND (("periodontitis"[MeSH Terms] OR "periodontitis"[All Fields]) AND ("premature birth"[MeSH Terms] OR ("premature"[All Fields] AND "birth"[All Fields]) OR "premature birth"[All Fields] OR ("preterm"[All Fields] AND "birth"[All Fields]) OR "preterm birth"[All Fields]))
Comments on
The Evidence
A meta-analysis of 11 prospective cohort studies supports this evidence. 12,173 patients were included in these studies. A comprehensive, detailed search for relevant trials was performed. These studies were assessed individually for validity. Further research is needed to verify the validity of this association because these studies are all progressive cohort studies, which cannot verify cause and effect as well as completely control for confounding factors.
Applicability Applicable to pregnant mothers with a history of periodontitis. The research subjects were from several different countries.
Specialty/Discipline (Periodontics) (Dental Hygiene)
Keywords "Periodontitis" and "pregnancy"
ID# 2113
Date of submission: 09/21/2011spacer
E-mail gallowayp@uthscsa.edu
Author Patrick Galloway
Co-author(s) e-mail
Faculty mentor/Co-author Richard Finlayson, DDS
Faculty mentor/Co-author e-mail finlaysonr@uthscsa.edu
Basic Science Rationale
(Mechanisms that may account for and/or explain the clinical question, i.e. is the answer to the clinical question consistent with basic biological, physical and/or behavioral science principles, laws and research?)
post a rationale
None available
Comments and Evidence-Based Updates on the CAT
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by Kayleigh Eaves (San Antonio, TX) on 07/10/2012
The second part of this Cochrane Analysis was recently published and continues to support this CAT. PMID 21736600

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